Platelet markers of suicidality.
Platelet markers of suicidality.
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自杀倾向的血小板标志物。
DOI：
10.1111/j.1749-6632.1986.tb27906.x
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发表时间：
1986
影响因子：
5.2
通讯作者：
Arora,RC
中科院分区：
文献类型：
--
作者：
Meltzer,HY;Arora,RC
测定抑郁症及其他精神疾病患者血小板中血清素能、血清素（5-HT）摄取Km和Vmax、3h -丙咪嗪结合Kd和Bmax、5-HT含量和MAO活性的6项指标，并与汉密尔顿抑郁量表自杀评分相关。Km与自杀率呈负相关，Kd与自杀率呈正相关。多变量分析显示，Km、Kd、Vmax和MAO活性是汉密尔顿抑郁量表自杀评分的显著预测因子。在本期有自杀企图的7名非抑郁女性中存在低血小板MAO活性。如果血小板检测结果可以推断为5-羟色胺神经末梢，那么血小板测量与自杀评分之间的关联方向表明，自杀评分高的患者突触前血清素能活性降低。
Six serotonergic measures in blood platelets, Km and Vmax of serotonin (5-HT) uptake, Kd and Bmax of 3H-imipramine binding, 5-HT content, and MAO activity, were measured in depressed and other psychiatric patients and related to Hamilton Depression Scale suicide ratings. Km was negatively correlated with the suicide rating while Kd was positively correlated with it. Multivariate analyses showed that Km, Kd, Vmax, and MAO activity were significant predictors of Hamilton Depression Scale suicide ratings. Low platelet MAO activity was present in seven nondepressed females who had made suicide attempts in the current episode. The direction of the association between the platelet measures and suicide ratings indicated diminished presynaptic serotonergic activity in patients with high suicide ratings, if the platelet findings could be extrapolated to 5-HT nerve terminals.