Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules.
Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules.
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DOI：
10.1128/mbio.01541-16
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发表时间：
2016-09-27
期刊：
影响因子：
6.4
通讯作者：
Miller SI
中科院分区：
文献类型：
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作者：
Miller SI
革兰氏阴性外膜是一个重要的屏障，可提供针对有毒化合物的保护，其中包括抗生素和宿主先天免疫分子，例如阳离子抗菌肽。最近，在了解外膜的生物发生、调节和功能方面取得了重大研究进展，包括不列颠哥伦比亚大学 Brett Finlay 博士实验室最近发表的一篇论文（J. van der Heijden 等人，mBio 7:e01238-16, 2016，http://dx.doi.org/10.1128/mBio.01541-16）。这些研究人员证明，有毒氧自由基（例如在宿主组织中发现的氧自由基）通过改变外膜孔蛋白通道来调节外膜通透性，从而调节氧自由基以及 β-内酰胺抗生素的流入。这篇评论提供了这篇有趣论文的背景，并讨论了利用增加的外膜生物学知识来开发针对抗生素耐药性革兰氏阴性细菌的新抗生素的前景。
The Gram-negative outer membrane is an important barrier that provides protection against toxic compounds, which include antibiotics and host innate immune molecules such as cationic antimicrobial peptides. Recently, significant research progress has been made in understanding the biogenesis, regulation, and functioning of the outer membrane, including a recent paper from the laboratory of Dr. Brett Finlay at the University of British Columbia (J. van der Heijden et al., mBio 7:e01238-16, 2016, http://dx.doi.org/10.1128/mBio.01541-16). These investigators demonstrate that toxic oxygen radicals, such as those found in host tissues, regulate outer membrane permeability by altering the outer membrane porin protein channels to regulate the influx of oxygen radicals as well as β-lactam antibiotics. This commentary provides context about this interesting paper and discusses the prospects of utilizing increased knowledge of outer membrane biology to develop new antibiotics for antibiotic-resistant Gram-negative bacteria.