[H-3] SPIPERONE BINDING, DOPAMINE AND HVA CONCENTRATIONS IN PARKINSONS-DISEASE AND SUPRANUCLEAR PALSY
[H-3] SPIPERONE BINDING, DOPAMINE AND HVA CONCENTRATIONS IN PARKINSONS-DISEASE AND SUPRANUCLEAR PALSY
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DOI：
10.1016/0014-2999(84)90238-3
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发表时间：
1984-01-01
影响因子：
5
通讯作者：
AGID, Y
中科院分区：
文献类型：
--
作者：
BOKOBZA, B;RUBERG, M;AGID, Y
尽管多巴胺能神经元大量受损，但帕金森病患者黑质、尾状核和伏隔核的d2型多巴胺受体密度（通过[3H]spiperone结合测定）正常，壳核的d2型多巴胺受体密度高于对照。壳核、尾状核和伏隔核的多巴胺水平分别降低了97%、85%和68%，黑质致密部和网状部的多巴胺水平分别降低了78%和93%。HVA[同香草酸]水平受到的影响要小得多，这表明剩余多巴胺能神经元活性的增加在一定程度上补偿了损伤。在帕金森患者中，抗精神病药物治疗和痴呆的存在影响了[3H]spiperone结合和多巴胺浓度。核上性麻痹患者纹状体中的多巴胺和HVA水平表明，这种疾病的黑质纹状体系统损伤程度与特发性帕金森病相同，但在所有结构研究中，spiperone结合减少了1/2。
The density of D2-type dopamine receptors, measured by the binding of [3H]spiperone was normal in the substantia nigra, caudate nucleus and nucleus accumbens of Parkinsonian subjects and above control levels in the putamen, in spite of massive lesions of the dopaminerigc neurons. Dopamine levels were reduced in the putamen, caudate nucleus, and nucleus accumbens by 97, 85 and 68%, respectively and by 78 and 93% of the pars compacta and pars reticulata of the substantia nigra. HVA [homovanillic acid] levels were much less affected suggesting that increased actiivty of the remaining dopaminergic neurons compensated to some extent for the lesions. Neuroleptic treatment and the presence of dementia in the Parkinsonian subjects affected [3H]spiperone binding and dopamine concentrations. Dopamine and HVA levels in the striatum of subjects with supranuclear palsy indicate that the nigrostriatal system was lesioned to the same degree in this disease as in idiopathic Parkinsonism, but spiperone binding was reduced by 1/2 in all the structures studies.