Interactions between helminth parasites and allergy.
Interactions between helminth parasites and allergy.
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DOI：
10.1097/aci.0b013e32831f44a6
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发表时间：
2009-02
影响因子：
2.8
通讯作者：
Cooper PJ
中科院分区：
文献类型：
--
作者：
Cooper PJ
这篇文章将回顾最近人类对蠕虫、寄生虫感染和过敏之间关系的研究结果，并讨论它们与公共卫生的潜在相关性。不同的寄生虫对过敏的影响可能不同，这可能取决于接触的时间。早期感染毛滴虫与晚年过敏原皮试反应发生率降低有关，据报道，感染蠕虫母亲的婴儿湿疹患病率降低。钩虫感染与埃塞俄比亚哮喘患病率的降低有关。一些研究报告说，抗蛔虫IgE是哮喘的一个重要危险因素，但这可以解释为特应性药物产生IgE的能力增强。弓形虫感染可能与某些人群中喘息风险的增加有关，这可能是由于宿主对寄生虫的反应或寄生虫对空气变应原增强的Th2反应引起的。虽然蠕虫感染可以调节针对寄生虫的宿主炎症反应，但蠕虫和特应性疾病之间的因果联系仍然不确定。
This article will review the findings of recent human studies of the association between helminth parasite infections and allergy and discuss their potential relevance to public health. Different helminth parasites may have different effects on allergy that may depend on the timing of the exposure. Infections with T. trichiura in early life are associated with a reduced prevalence of allergen skin test reactivity later in life and infants of helminth-infected mothers have been reported to have a reduced prevalence of eczema. Hookworm infection has been associated with a reduced prevalence of asthma in Ethiopia. Several studies have reported that anti-Ascaris IgE is an important risk factor for asthma, but this could be explained by an enhanced ability of atopics to produce IgE. Toxocara infections may be associated with an increased risk of wheeze in some populations that may be caused by the host response to the parasite or by parasite-enhanced Th2 responses to aeroallergens. Although helminth infections can modulate the host inflammatory response directed against the parasite, a causal association between helminths and atopic diseases remains uncertain.