Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells.
Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells.
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DOI：
10.1007/s11274-011-0745-z
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发表时间：
2011-11-01
影响因子：
4.1
通讯作者：
Ijdo, Jacob W.
中科院分区：
文献类型：
--
作者：
Karki, Pratap;Ijdo, Jacob W.
Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intra-cellular bacterium that survives in neutrophils by delaying apoptosis. The human promyelocytic leukemia cell line HL-60 has been the ultimate choice for culturing Anaplasma in vitro. In this study, we assessed the various events of drug-induced apoptosis in A. phagocytophilum-infected HL-60 cells. Anaplasma infection reduced the cell viability and increased the apoptosis in HL-60 cells and staurosporine or etoposide-induced apoptosis was further exacerbated with Anaplasma infection. Altogether our results suggest that A. phagocytophilum infection is proapoptotic in HL-60 cells unlike in neutrophils where it is antiapoptotic.
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