A Continuing Career in Biocatalysis: Frances H. Arnold
A Continuing Career in Biocatalysis: Frances H. Arnold
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DOI：
10.1021/acscatal.9b02737
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发表时间：
2019-11-01
期刊：
影响因子：
12.9
通讯作者：
Zhao, Huimin
中科院分区：
文献类型：
--
作者：
Fasan, Rudi;Kan, S. B. Jennifer;Zhao, Huimin
在弗朗西斯·H.阿诺德最近接受了2018年诺贝尔化学奖，我们荣誉她在定向进化和生物催化领域的众多贡献。阿诺德率先开发了定向进化方法，将酶工程化为生物催化剂。她高度跨学科的研究不仅为理解酶的进化机制提供了基础，也为开发商业上可行的酶生物催化剂和生物催化过程提供了基础。在本报告中，我们重点介绍了她在过去三十年中在基础定向进化方法的发展及其在具有生物催化所需功能的酶的设计和工程中的应用方面的一些显着贡献。她的工作在广泛的催化领域创造了一个范式转变。
On the occasion of Professor Frances H. Arnold's recent acceptance of the 2018 Nobel Prize in Chemistry, we honor her numerous contributions to the fields of directed evolution and biocatalysis. Arnold pioneered the development of directed evolution methods for engineering enzymes as biocatalysts. Her highly interdisciplinary research has provided grounds not only for understanding the mechanisms of enzyme evolution but also for developing commercially viable enzyme biocatalysts and biocatalytic processes. In this Account, we highlight some of her notable contributions in the past three decades in the development of foundational directed evolution methods and their applications in the design and engineering of enzymes with desired functions for biocatalysis. Her work has created a paradigm shift in the broad catalysis field.