Hyperprolactinemia counteracts the testosterone-induced inhibition of the preoptic area dopamine turnover.
Hyperprolactinemia counteracts the testosterone-induced inhibition of the preoptic area dopamine turnover.
复制标题
高催乳素血症可以抵消睾酮引起的视前区多巴胺周转的抑制。
DOI：
10.1159/000123214
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发表时间：
1981
影响因子：
4.1
通讯作者：
Kalra,SP
中科院分区：
文献类型：
--
作者：
Kalra,PS;Simpkins,JW;Kalra,SP
本研究旨在观察高泌乳素血症对去势和去势睾丸酮（T）植入雄性大鼠下丘脑内侧基底核（MBH）和视前区-视交叉上核区（POA-SCN）多巴胺（DA）含量和转换率的影响。皮下植入物，血清T水平提高到那些发现在完整的大鼠，血清LH下降到基础水平，但没有改变DA营业额的MBH。肾包膜下垂体前叶（AP）移植增加血清催乳素60-110 ng/ml，并加速DA周转近2倍，在MBH的去势和去势，T植入大鼠不影响血清LH水平。虽然T植入物导致POA-SCN DA营业额下降，但去势大鼠中AP植入物产生的高血清催乳素水平在改变POA-SCN DA营业额方面无效。然而，在生理水平的T的存在下，这些升高的血清催乳素水平不仅阻止了T诱导的POA-SCN DA营业额的下降，但进一步增强DA营业额超过在去势或去势，T植入大鼠中观察到的。这些结果表明：（i）催乳素T引发对MBH DA周转的加速作用不是必需的，它似乎发生在血清催乳素水平不抑制血清LH水平的情况下;（ii）催乳素对POA-SCN DA周转的刺激作用依赖于循环T的存在。由于这些协同作用的催乳素和T的POA-SCN DA营业额不参与调节促性腺激素分泌，他们参与衰减与高催乳素血症相关的男性性行为进行了讨论。
The present study was undertaken to determine the effects of hyperprolactinemia on dopamine (DA) concentrations and turnover rates in the medial basal hypothalamus (MBH) and the preoptic area-suprachiasmatic nucleus region (POA-SCN) in castrated and castrated, testosterone (T) implanted male rats. Subcutaneous implants, which raised serum T levels to those found in intact rats, decreased serum LH to basal levels but did not alter DA turnover in the MBH. Anterior pituitary (AP) transplants under the renal capsule increased serum prolactin to 60–110 ng/ml, and accelerated DA turnover by nearly 2-fold in the MBH of both castrated and castrated, T-implanted rats without influencing serum LH levels. While T implants caused a decrease in the POA-SCN DA turnover, high serum prolactin levels produced by AP implants in castrated rats were ineffective in altering POA-SCN DA turnover. However, in the presence of physiological levels of T, these elevated serum prolactin levels not only blocked the T-induced decrease in POA-SCN DA turnover, but further augmented DA turnover over that observed in the castrated or castrated, T-implanted rats. These results indicate that (i) for acceleration of the MBH DA turnover by prolactin T priming is not essential and it appears to occur at serum prolactin levels which do not depress serum LH levels, and (ii) the stimulatory effects of prolactin on the POA-SCN DA turnover are dependent upon the presence of circulating T. Since these synergistic effects of prolactin and T on the POA-SCN DA turnover are not involved in the regulation of gonadotropin secretion, their participation in attenuation of male sexual behavior associated with hyperprolactinemia is discussed.