Evidence for age-related cochlear synaptopathy in humans unconnected to speech-in-noise intelligibility deficits
Evidence for age-related cochlear synaptopathy in humans unconnected to speech-in-noise intelligibility deficits
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DOI：
10.1016/j.heares.2019.01.017
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发表时间：
2019-03-15
期刊：
影响因子：
2.8
通讯作者：
Lopez-Poveda, Enrique A.
中科院分区：
文献类型：
--
作者：
Johannesen, Peter T.;Buzo, Byanka C.;Lopez-Poveda, Enrique A.
耳蜗突触病（或初级听觉突触的丧失）仍然是一种患病率不确定的亚临床状态。在这里，我们研究它是否会影响人类，以及它是否会导致超阈值的语音噪音可理解性缺陷。对于94名听力正常的人类听众（年龄12-68岁；64名女性），我们测量了点击诱发的听觉脑干反应（abr），自我报告的终生噪音暴露，以及在稳态和波动掩蔽器下句子（65 dB SPL）和单词（50,65和80 dB SPL）的语音接收阈值。基于动物实验，我们假设ABR波i振幅相对于水平功能的生长速率越浅，患突触病的风险越高。我们发现波i生长速率随年龄的增加而下降，但不随噪声暴露的增加而下降。噪声下的语音接收阈值与波i生长速率不相关，两组（N = 14）听力图匹配（最高达12 kHz）但波i生长速率不同的参与者的平均语音接收阈值无统计学差异。总之，这些数据与年龄相关而非噪声相关的突触病的存在是一致的。此外，这些数据对突触病变导致噪音中言语可理解性缺陷的观点提出了质疑。(C) 2019 Elsevier B.V.版权所有
Cochlear synaptopathy (or the loss of primary auditory synapses) remains a subclinical condition of uncertain prevalence. Here, we investigate whether it affects humans and whether it contributes to suprathreshold speech-in-noise intelligibility deficits. For 94 human listeners with normal audiometry (aged 12-68 years; 64 women), we measured click-evoked auditory brainstem responses (ABRs), self-reported lifetime noise exposure, and speech reception thresholds for sentences (at 65 dB SPL) and words (at 50, 65 and 80 dB SPL) in steady-state and fluctuating maskers. Based on animal research, we assumed that the shallower the rate of growth of ABR wave-I amplitude versus level function, the higher the risk of suffering from synaptopathy. We found that wave-I growth rates decreased with increasing age but not with increasing noise exposure. Speech reception thresholds in noise were not correlated with wave-I growth rates and mean speech reception thresholds were not statistically different for two subgroups of participants (N = 14) with matched audiograms (up to 12 kHz) but different wave-I growth rates. Altogether, the data are consistent with the existence of age-related but not noise-related synaptopathy. In addition, the data dispute the notion that synaptopathy contributes to suprathreshold speech-in-noise intelligibility deficits. (C) 2019 Elsevier B.V. All rights reserved.