Missing or altered self: human NK cell receptors that recognize HLA-C.
Missing or altered self: human NK cell receptors that recognize HLA-C.
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DOI：
10.1007/s00251-017-1001-y
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发表时间：
2017-08
期刊：
影响因子：
3.2
通讯作者：
Parham P
中科院分区：
文献类型：
--
作者：
Hilton HG;Parham P
自然杀伤(NK)细胞是一种快速反应的多功能淋巴细胞，对天然免疫、获得性免疫和胎盘发育至关重要。NK细胞功能的调控是杀伤细胞免疫球蛋白样受体(KIRS)与其HLA-A、-B、-C配体之间的相互作用。由于KIR和HLAI类基因的广泛多态性，这些相互作用是高度多样化的，并且特定的组合与对一系列传染病、自身免疫和生殖疾病的保护或易感性相关。进化、遗传学和功能研究表明，KIR和人类白细胞抗原C之间的相互作用是人类NK细胞的主要调控机制。除了它们对C1和C2表位的识别外，越来越多的证据表明，KIR对人类白细胞抗原-C提出的多肽具有以前未被认识到的选择性。这种选择性似乎是激活KIR的保守特征，可能在一定程度上解释了在识别其HLAI类配体方面进展缓慢的原因。KIR的多肽选择性使NK细胞不仅对HLA-C表面表达的变化做出反应，而且对发生在病毒感染和恶性转化过程中的HLA-C多肽组的更细微的变化做出反应。在这里，我们综述了关于人类特异性KIR进化的最新进展，以及抑制和激活人类白细胞抗原-C受体如何使NK细胞对健康细胞、患病细胞和胎儿的半异基因细胞产生反应。
Natural killer (NK) cells are fast-acting and versatile lymphocytes that are critical for innate immunity, adaptive immunity and placental development. Controlling NK cell function are interactions between killer-cell immunoglobulin-like receptors (KIRs) and their HLA-A, -B and -C ligands. Due to the extensive polymorphism of both KIR and HLA class I, these interactions are highly diversified and specific combinations correlate with protection or susceptibility to a range of infectious, autoimmune and reproductive disorders. Evolutionary, genetic and functional studies are consistent with the interactions between KIR and HLA-C being the dominant control mechanism of human NK cells. In addition to their recognition of the C1 and C2 epitopes, increasing evidence points to KIR having a previously unrecognized selectivity for the peptide presented by HLA-C. This selectivity appears to be a conserved feature of activating KIR and may partly explain the slow progress made in identifying their HLA class I ligands. The peptide selectivity of KIR allows NK cells to respond, not only to changes in the surface expression of HLA-C, but also to the more subtle changes in the HLA-C peptidome, such as occur during viral infection and malignant transformation. Here we review recent advances in understanding of human-specific KIR evolution and how the inhibitory and activating HLA-C receptors allow NK cells to respond to healthy cells, diseased cells and the semi-allogeneic cells of the fetus.
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DOI：
10.4049/jimmunol.1001494
发表时间：
2010-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Older Aguilar AM;Guethlein LA;Adams EJ;Abi-Rached L;Moesta AK;Parham P
通讯作者：
Parham P
影响因子：
5.5
作者：
Chandran, Vinod;Bull, Shelley B.;Gladman, Dafna D.
通讯作者：
Gladman, Dafna D.
影响因子：
3.2
作者：
Aguilar, Anastazia M. Older;Guethlein, Lisbeth A.;Parham, Peter
通讯作者：
Parham, Peter
影响因子：
3.7
作者：
Besson C;Roetynck S;Williams F;Orsi L;Amiel C;Lependeven C;Antoni G;Hermine O;Brice P;Ferme C;Carde P;Canioni D;Brière J;Raphael M;Nicolas JC;Clavel J;Middleton D;Vivier E;Abel L
通讯作者：
Abel L
影响因子：
--
作者：
Estefania, E.;Gomez-Lozano, N.;Vilches, C.
通讯作者：
Vilches, C.