Visceral Fat Volume and the Prevalence of Colorectal Adenoma
Visceral Fat Volume and the Prevalence of Colorectal Adenoma
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DOI：
10.1093/aje/kwp311
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发表时间：
2009-12-15
影响因子：
5
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Yamaji, Taiki;Iwasaki, Motoki;Tsugane, Shoichiro
内脏脂肪和结直肠肿瘤的流行病学调查很少尝试直接定量内脏脂肪。作者测量了2004年2月至2005年2月期间在日本东京接受结肠镜检查和正电子发射断层扫描/计算机断层扫描进行癌症筛查的日本中年和老年男性和女性的内脏脂肪体积，并在1，205名合格受试者中检查了内脏脂肪与结直肠腺瘤之间的关系。在调整潜在混杂因素后，采用非条件logistic回归模型估计结直肠腺瘤的优势比和95%置信区间。尽管内脏脂肪体积与体重指数高度相关，但无论男女，内脏脂肪体积与结直肠腺瘤的患病率相关，而与体重指数无关。在进一步调整体重指数后，男性和女性合并的内脏脂肪体积最高与最低四分位数的结直肠腺瘤的比值比为1.58（95%置信区间：1.11，2.24）。相反，体重指数不太可能改变内脏脂肪体积和结直肠腺瘤之间的关联（P-相互作用= 0.39）。这些发现为内脏肥胖对结直肠肿瘤的发病机制产生重要影响提供了更多的证据。内脏肥胖和结直肠癌发生之间的潜在联系的机制值得进一步研究。
Few epidemiologic investigations of visceral adiposity and colorectal neoplasms have attempted the direct quantification of visceral fat. The authors measured visceral fat volume among middle-aged and elderly Japanese men and women who underwent colonoscopy and positron emission tomography/computed tomography for cancer screening in Tokyo, Japan, between February 2004 and February 2005, and examined the association between visceral adiposity and colorectal adenoma in 1,205 eligible subjects. Odds ratios and 95% confidence intervals for colorectal adenoma were estimated by using an unconditional logistic regression model after adjustment for potential confounders. Despite its high correlation with body mass index, visceral fat volume was associated with the prevalence of colorectal adenoma independently of body mass index in both sexes. After further adjustment for body mass index, the odds ratio of colorectal adenoma for the highest compared with the lowest quartile of visceral fat volume was 1.58 (95% confidence interval: 1.11, 2.24) for men and women combined. Conversely, body mass index was unlikely to modify the association between visceral fat volume and colorectal adenoma (P-interaction = 0.39). These findings add to accumulating evidence that visceral adiposity exerts an important influence on the pathogenesis of colorectal neoplasms. The mechanisms of this potential association between visceral adiposity and colorectal carcinogenesis warrant further investigation.