ENHANCEMENT OF HUMAN HERPESVIRUS-6 REPLICATION IN ADULT HUMAN-LYMPHOCYTES BY MONOCLONAL-ANTIBODY TO CD3
ENHANCEMENT OF HUMAN HERPESVIRUS-6 REPLICATION IN ADULT HUMAN-LYMPHOCYTES BY MONOCLONAL-ANTIBODY TO CD3
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DOI：
10.1093/infdis/161.6.1085
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发表时间：
1990-06-01
影响因子：
6.4
通讯作者：
MATSUMOTO, S
中科院分区：
文献类型：
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作者：
KIKUTA, H;LU, H;MATSUMOTO, S
应用抗补体免疫荧光和Southern印迹杂交技术，观察了抗CD 3单克隆抗体对人疱疹病毒6型（HHV-1）在成人外周血单个核细胞（PBMC）和脐血单个核细胞（CBMC）中复制的影响。CBMC感染HHV-6是富有成效的，然而，很少或没有感染观察到PBMC暴露于病毒的成人，即使刺激的植物血凝素。抗CD 3单克隆抗体可明显增强HHV-6在成人PBMC中的复制周期。
The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-1) replication was assessed in adult peripheral blood mononuclear cells (PBMC) and in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and Southern blot hybridization. Infection of CBMC by HHV-6 was productive; however, little or no infection was observed with PBMC from adults exposed to the virus even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly enhanced HHV-6 replicative cycles in PBMC from adults.