The MR detection of neuronal depolarization during 3-Hz spike-and-wave complexes in generalized epilepsy
The MR detection of neuronal depolarization during 3-Hz spike-and-wave complexes in generalized epilepsy
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DOI：
10.1016/j.mri.2004.10.017
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发表时间：
2004-12-01
影响因子：
2.5
通讯作者：
Lemieux, L
中科院分区：
文献类型：
--
作者：
Liston, AD;Salek-Haddadi, A;Lemieux, L
此前，Salek-Haddadi提出了一项使用脑电图相关功能磁共振成像（MRI）在3 Hz全身性棘波放电（GSWD）运行期间对特发性全身性癫痫患者观察到的激活进行分析。据报道，时间锁定的、双侧、丘脑血氧水平依赖性增加伴随着广泛的、对称的、具有额叶最大值的皮质失活。鉴于最近的研究MRI检测的磁场扰动引起的神经元电流回路在去极化，我们重新Salek-Haddadi的数据分析作为一个初步的搜索神经电信号。我们将MRI响应建模为快速信号和慢速信号的总和，并在与GSWD相关的30 ms量级的时间尺度上证明了显著的MRI活动。在对这一信号的性质得出确切的结论之前，有必要开展进一步的工作。(C)2004年爱思唯尔公司All rights reserved.
Previously, an analysis of activations observed in a patient with idiopathic generalized epilepsy using electroencephalogram-correlated functional magnetic resonance imaging (MRI) during runs of 3-Hz generalized spike-wave discharge (GSWD) was presented by Salek-Haddadi. Time-locked, bilateral, thalamic blood oxygenation level-dependent increases were reported to be accompanied by widespread, symmetric, cortical deactivation with a frontal maximum. In light of recent investigations into MRI detection of the magnetic field perturbations caused by neuronal current loops during depolarization, we revisited the analysis of the data of Salek-Haddadi as a preliminary search for a neuroelectric signal. We modeled the MRI response as the sum of a fast signal and a slower signal and demonstrated significant MRI activity at a time scale of the order of 30 ms associated with GSWDs. Further work is necessary before firm conclusions may be drawn about the nature of this signal. (C) 2004 Elsevier Inc. All rights reserved.