Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity
Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity
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DOI：
10.1073/pnas.0707171104
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发表时间：
2007-09-18
影响因子：
11.1
通讯作者：
Fox, Howard S.
中科院分区：
文献类型：
--
作者：
Huitron-Resendiz, Salvador;Marcondes, Maria Cecilia G.;Fox, Howard S.
在感染猴免疫缺陷病毒(SIV)的猴子中，体温和运动活动的变化发生在疾病的急性逆转录病毒综合症阶段之后。然而，在感染SIV的猴子中，这些因素的昼夜节律的变化还没有报道。为了确定SIV感染期间体温和活动的昼夜节律是否被打乱，我们分析了SIV感染的猴子在疾病的不同阶段的温度和活动模式，并利用昼夜振荡的Cosinor模型进行了分析。我们发现，SIV感染导致体温和活动的昼夜节律的幅度和平均值以及体温昼夜节律的高峰期显著受损。这些变化与观察到的病毒接种后引起的急性发热反应的变化无关。在被处死的动物中，一旦出现明显的昼夜节律异常，就会在下丘脑观察到小胶质细胞的浸润和巨噬细胞的聚集。综上所述，这些结果清楚地表明，SIV感染损害了猴子昼夜节律的某些方面，对艾滋病毒感染者的生理功能包括认知具有重要影响。
In monkeys infected with simian immunodeficiency virus (SIV), changes in body temperature and locomotor activity occur after the acute retroviral syndrome stage of the disease. However, alterations to the circadian rhythm of these factors in SIV-infected monkeys have not been reported. To determine whether the circadian rhythm of body temperature and locomotor activity are disrupted during SIV infection, we analyzed the temperature and activity patterns of SIV-infected monkeys through different stages of the disease, progressing to SIV encephalitis by using the cosinor model for circadian oscillation. We found that SIV infection resulted in significant impairments of the amplitude and mean of the circadian rhythm of body temperature and activity and in the acrophase of the circadian rhythm for temperature. These alterations were not related to changes observed in the acute febrile response induced after viral inoculation. In animals killed once marked circadian anomalies were evident, microglia infiltration and macrophage accumulation in the hypothalamus were observed. Together, these results clearly demonstrate that SIV infection compromises aspects of circadian regulation in monkeys, with important implications for physiological functions, including cognition, in HIV-infected individuals.