Indoor air pollution from solid fuel use, chronic lung diseases and lung cancer in Harbin, Northeast China
Indoor air pollution from solid fuel use, chronic lung diseases and lung cancer in Harbin, Northeast China
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DOI：
10.1097/cej.0b013e328305a0b9
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发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Hu, Jinfu
中科院分区：
文献类型：
--
作者：
Galeone, Carlotta;Pelucchi, Claudio;Hu, Jinfu
在中国的一些地区，主要源于固体燃料燃烧的室内空气污染与肺癌有相关的作用。以前的大多数研究都集中在女性群体上，只有少数研究是针对两性的。本文分析了东北中国哈尔滨市男女肺癌基线风险都很高的地区，固体燃料使用所致间歇性肺炎与慢性肺部疾病的关系。我们使用了1987至1990年间进行的病例对照研究的数据，其中包括218名经组织学证实的意外肺癌患者和436名在同一家医院住院的对照病例。我们使用取暖类型、烹饪燃料使用量和房屋测量数据计算了使用固体燃料暴露的IAP指数。家庭取暖和/或做饭接触煤燃料的病例比对照组多，永远接触煤燃料与从未接触煤燃料的优势比(OR)为2.19[95%可信区间(CI)：1.08~4.46]。与最低三分位数相比，按IAP暴露指数三分位数计算肺癌的OR值分别为1.82(95%CI：1.14~2.89)和1.99(95%CI：1.26~3.15)。有慢性支气管炎和肺结核病史的人群患肺癌的OR值分别为3.79(95%CI：2.38~6.02)和3.82(95%CI：1.97~7.41)。这项研究进一步支持和量化了IAP、选定的非恶性肺部疾病病史和男女肺癌风险之间的正相关关系。
In some areas of China, indoor air pollution (IAP) originating principally from the combustion of solid fuels has a relevant role in lung cancer. Most previous studies focused on the female population and only a few on both the sexes. We analyzed the relationship between IAP from solid fuel use and selected chronic lung diseases and lung cancer risk in Harbin, Northeast China, an area with a very high base line risk of lung cancer for both the sexes. We used data from a case-control study conducted between 1987 and 1990, including 218 patients with incident, histologically confirmed lung cancer and 436 controls admitted to the same hospitals as cases. We calculated an index of IAP from solid fuel use exposure using data on heating type, cooking fuel used, and house measurements. Cases reported more frequently than controls an exposure to coal fuel for house heating and/or cooking, and the odds ratio (OR) for ever versus never exposed was 2.19 [95% confidence interval (CI): 1.08-4.46]. The ORs of lung cancer according to subsequent tertiles of IAP exposure index were 1.82 (95% CI: 1.14-2.89) and 1.99 (95% CI: 1.26-3.15) as compared with the lowest tertile. The ORs of lung cancer for participants with a history of chronic bronchitis and tuberculosis were 3.79 (95% CI: 2.38-6.02) and 3.82 (95% CI: 1.97-7.41), respectively. This study gives further support and quantification of the positive association between IAP, history of selected nonmalignant lung diseases, and lung cancer risk for both the sexes.