Mechanically stable tantalum coating on a nano-roughened NiTi stent for enhanced radiopacity and biocompatibility
Mechanically stable tantalum coating on a nano-roughened NiTi stent for enhanced radiopacity and biocompatibility
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DOI：
10.1016/j.surfcoat.2016.08.014
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发表时间：
2016-11-15
影响因子：
5.4
通讯作者：
Jang, Tae-Sik
中科院分区：
文献类型：
--
作者：
Park, Cheonil;Kim, Sungwon;Jang, Tae-Sik
为了提高镍钛(NiTi)合金的辐射不透过性和生物相容性，在纳米粗化和掺Ta的镍钛(NiTi)合金表面沉积了机械稳定的Ta涂层。采用靶离子诱导等离子体溅射工艺在注入Ta的NiTi合金表面制备了高度均匀的纳米级粗糙度。场发射扫描电子显微镜、X射线衍射仪和透射电子显微镜的表征表明，致密的α相Ta涂层通过纳米粗糙的界面结构紧密地结合在NiTi衬底上。用划痕试验和拉伸试验分别考察了Ta涂层的机械稳定性和延伸性。与平坦表面相比，纳米粗糙表面Ta涂层的结合强度和机械稳定性有显著提高。X射线显微图像显示，涂层对X射线吸收系数高、厚度大，提高了镍钛支架的不透射线性能。体外细胞黏附和MTS检测表明，Ta涂层有利于内皮细胞的黏附和增殖。这些结果表明，在纳米粗糙的NiTi上沉积Ta涂层显著提高了NiTi支架的机械稳定性、放射不透明度和生物相容性。(C)2016爱思唯尔B.V.保留所有权利。
Mechanically stable tantalum (Ta) coatings were deposited onto nano-roughened and Ta-incorporated nickel-titanium (NiTi) alloy substrates to enhance their radiopacity and biocompatibility. A target-ion induced plasma sputtering process was used to induce highly uniform nanoscale roughness on the NiTi alloys, with Ta implantation. Characterization by field-emission scanning electron microscopy, X-ray diffraction, and transmission electron microscopy revealed that a dense alpha-phase Ta coating layer was tightly anchored to the NiTi substrate via the nano-roughened interface structures. The mechanical stability and stretchability of the Ta coating was examined using scratch and tensile tests, respectively. The adhesion strength and mechanical stability of the Ta coating on the nano-roughened NiTi surface showed remarkable improvement compared with the Ta coating on a flat NiTi surface. X-ray microscopic images showed that the radiopacity of a NiTi stent was enhanced by the Ta coating layer because of its high X-ray absorption coefficient and large thickness. In vitro cell adhesion and MTS assay revealed that the Ta coating was beneficial for endothelial cell attachment and proliferation. These results demonstrate that the Ta coating deposited onto nano-roughened NiTi substantially improved the mechanical stability, radiopacity, and biocompatibility of the NiTi stent. (C) 2016 Elsevier B.V. All rights reserved.