Higher HIV-1 incidence and genetic complexity along main roads in Rakai District, Uganda
Higher HIV-1 incidence and genetic complexity along main roads in Rakai District, Uganda
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DOI：
10.1097/01.qai.0000243053.80945.f0
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发表时间：
2006-12-01
影响因子：
3.6
通讯作者：
McCutchan, Francine E.
中科院分区：
文献类型：
--
作者：
Arroyo, Miguel A.;Sateren, Warren B.;McCutchan, Francine E.
目的：确定乌干达拉凯地区2个地理阶层中HIV-1感染发生率与HIV-1毒株遗传复杂性之间的关联。方法：在1997年至2003年期间最近感染HIV-1的研究志愿者从10个社区招募，这些社区在地理上被分层为主要道路贸易中心（n = 5）或次要道路贸易村（n = 5）。5）。冻存血浆来自384名志愿者，是多区域杂交试验基因分型的病毒RNA来源。使用考克斯比例风险分析获得的风险比（HR）为一个单一的艾滋病毒亚型，重组形式，或双重感染的性别和地理分层。结果：在1999年至2002年期间的HIV-1的发病率为1.3每100人年（PYs）的贸易中心和1.1每100 PYs的贸易村。交易中心相对于交易村感染HIV-1重组株的HR为2.3（95%置信区间[CI]：1.0 - 6.7）。在那些谁改变居住在村庄之间的阶层，重组HIV-1感染的HR为8.1（95% CI：0.4至47.7）。结论：HIV-1的发病率和遗传复杂性与地理阶层和人口流动性在Rakai区，是重要的变量，在规划和招募疫苗试验中要考虑。
Objective: To determine the association between the incidence of HIV-1 infection and the genetic complexity of HIV-1 strains in 2 geographic strata within Rakai District, Uganda.Methods: Study volunteers with recent HIV-1 infections during the period 1997 through 2003 were recruited from 10 communities that were geographically stratified as a main road trading center (n = 5) or a secondary road trading village (n = 5). Cryopreserved plasma was available from 384 volunteers and was the source of viral RNA for genotyping by the multiregion hybridization assay. Hazard ratios (HRs) for a single HIV subtype, a recombinant form, or dual infection for gender and geographic strata were obtained using Cox proportional hazards analysis.Results: The HIV-1 incidence rate during the period 1999 through 2002 was 1.3 per 100 person-years (PYs) in the trading centers and 1.1 per 100 PYs in the trading villages. The HR for infection with an HIV-1 recombinant strain in trading centers relative to trading villages was 2.3 (95% confidence interval [Cl]: 1.0 to 6.7). Among those who changed residence between village strata, the HR for a recombinant HIV-1 infection was 8.1 (95% Cl: 0.4 to 47.7).Conclusions: HIV-1 incidence and genetic complexity are associated with geographic strata and population mobility in Rakai District and are important variables to be considered in planning and recruitment for vaccine trials.