Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults
Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults
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DOI：
10.1093/gerona/glp038
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发表时间：
2009-08-01
影响因子：
5.1
通讯作者：
Takebayashi, Toru
中科院分区：
文献类型：
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作者：
Michikawa, Takehiro;Nishiwaki, Yuji;Takebayashi, Toru
本研究的目的是评估日本老年人血清视黄醇和其他抗氧化剂水平与听力障碍之间的关系。这是一项基于社区的横断面研究，包括日本群马市仓渊市762名65岁或以上的居民。我们测量血清视黄醇和其他抗氧化剂（α-和γ-生育酚，类胡萝卜素，包括β-隐黄质，α-和β-胡萝卜素，番茄红素，叶黄素加玉米黄质）的高效液相色谱法，并将每个测量分为四分位数。听力障碍被定义为在纯音听力测试中，较好的一只耳朵在1 kHz时听不到30 dB听力水平（HL）信号，在4 kHz时听不到40 dB HL信号。听力障碍的优势比（OR）计算的每一个上三个四分位数的视黄醇和其他抗氧化剂水平相对于最低quartilite.Crude分析表明，血清水平的视黄醇和维生素原A类胡萝卜素（β-隐黄素，α-和β-胡萝卜素）呈负相关的听力障碍的患病率。最高四分位数的视黄醇和维生素原A家族（维生素原A类胡萝卜素的组合）与最低四分位数相比的多重调整OR（95%置信区间）分别为0.51（0.26-1.00）和0.53（0.27-1.02）。视黄醇（p = 0.03）和维生素原A（p = 0.09）存在剂量反应关系。血清中视黄醇和维生素原A类胡萝卜素水平的升高与听力障碍患病率的降低明显相关。
The objective of this study was to assess the relation between serum levels of retinol and other antioxidants and hearing impairment in Japanese older adults.This is a community-based cross-sectional study comprising 762 residents aged 65 years or older in Kurabuchi, Gumma, Japan. We measured serum retinol and other antioxidants (alpha- and gamma-tocopherols, and carotenoids including beta-cryptoxanthin, alpha- and beta-carotenes, lycopene, and lutein plus zeaxanthin) by high-performance liquid chromatography and divided each measurement into quartiles. Hearing impairment was defined as a failure to hear a 30-dB hearing level (HL) signal at 1 kHz and a 40-dB HL signal at 4 kHz in the better ear in pure-tone audiometric tests. The odds ratios (OR) for hearing impairment were calculated for each of the upper three quartiles of retinol and other antioxidant levels relative to the lowest quartile.Crude analysis showed that serum levels of retinol and provitamin A carotenoids (beta-cryptoxanthin, and alpha- and beta-carotenes) were inversely related to the prevalence of hearing impairment. The multiadjusted ORs (95% confidence intervals) for the highest quartile of retinol and the provitamin A family (combinations of provitamin A carotenoids) compared with the lowest were 0.51 (0.26-1.00) and 0.53 (0.27-1.02), respectively. A dose-response relationship was observed for retinol (p = .03) and provitamin A (p = .09).Increased serum levels of retinol and provitamin A carotenoids were clearly associated with a decreased prevalence of hearing impairment.