Biodegradability of poly(lactic-co-glycolic acid) irradiated with femtosecond laser pulses without material removal
Biodegradability of poly(lactic-co-glycolic acid) irradiated with femtosecond laser pulses without material removal
复制标题
DOI：
10.1007/s00339-019-2433-z
复制
发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Naonari Kondo;M. Terakawa
中科院分区：
文献类型：
--
作者：
Naonari Kondo;M. Terakawa
生物可降解聚合物的降解速率对于组织支架应用是必须控制的。在这项工作中，我们证明了聚（乳酸-羟基乙酸共聚物）（PLGA）的降解速率通过在材料去除，即，没有发生激光消融。扫描电子显微镜观察表明，在没有明显激光烧蚀的情况下，降解速率加快。傅里叶变换红外光谱和X射线光电子能谱的分析表明，飞秒激光脉冲照射的PLGA的化学性质发生了变化。此外，我们研究了当飞秒激光脉冲聚焦在材料内部时PLGA的降解。降解后，PLGA在距离表面300 µm的深度处显示出增强的光学散射区域。结果表明，在不直接去除材料的条件下，通过改变飞秒激光脉冲的焦深，可以实现高深宽比的改性和降解。
The degradation rates of biodegradable polymers are necessary to be controlled for tissue scaffold applications. In this work, we demonstrate that the degradation rate of poly(lactic-co-glycolic acid) (PLGA) was accelerated by irradiating with femtosecond laser pulses under the condition where material removal, i.e., laser ablation had not occurred. Scanning electron microscopy observation showed that the degradation rate was accelerated without significant laser ablation. The analysis of Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy revealed that the chemical properties of the PLGA had changed by femtosecond laser pulses irradiation. Furthermore, we have investigated the degradation of PLGA when the femtosecond laser pulses were focused inside the material. After the degradation, the PLGA showed enhanced optical scattering region in the depth of 300 µm from the surface. The results indicate that high-aspect-ratio modification and degradation are possible by changing the depth of focus of femtosecond laser pulses under the conditions where the direct removal of the material was not occurred.