Intestinal epithelial-mesenchymal cell interactions
Intestinal epithelial-mesenchymal cell interactions
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DOI：
10.1111/j.1749-6632.1998.tb11107.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Freund, JN
中科院分区：
文献类型：
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作者：
Kedinger, M;Duluc, I;Freund, JN
肠道形态发生以及干细胞群的维持以及细胞增殖和分化之间的稳态的维持是受控的细胞相互作用的结果。越来越多的证据表明，间充质细胞通过其自身在上皮细胞中表达和诱导关键调节基因来控制上皮细胞行为。这种异源串扰涉及基底膜分子和旁分泌因子。新的体外/体内细胞模型使我们能够分析各种间充质细胞表型，并表明它们对上皮细胞表现出不同的诱导特性，并且它们的增殖和代谢特性受到细胞因子的差异调节。最后，上皮间质单位受激素和外源因素控制。
Intestinal morphogenesis, as well as maintenance of the stem cell population and of the steady state between cell proliferation and differentiation, results from controlled cell interactions. There is growing evidence that the mesenchymal cells control epithelial cell behavior via their own expression and induction in the epithelial cells of key regulatory genes. This heterologous cross talk involves basement membrane molecules and paracrine factors. New in vitro/in vivo cellular models allowed us to analyze various mesenchymal cell phenotypes and to show that they exhibit different inductive properties on epithelial cells and that their proliferation and metabolic properties are differentially modulated by cytokines. Finally the epithelial-mesenchymal unit is controlled by hormonal and exogenous factors.