A Systematic Review and Meta-Analysis on the Prevalence of Dementia in Europe: Estimates from the Highest-Quality Studies Adopting the DSM IV Diagnostic Criteria.
A Systematic Review and Meta-Analysis on the Prevalence of Dementia in Europe: Estimates from the Highest-Quality Studies Adopting the DSM IV Diagnostic Criteria.
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DOI：
10.3233/jad-180416
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Vanacore N
中科院分区：
文献类型：
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作者：
Bacigalupo I;Mayer F;Lacorte E;Di Pucchio A;Marzolini F;Canevelli M;Di Fiandra T;Vanacore N
痴呆症，包括阿尔茨海默病 (AD)，是最令人负担的疾病之一。通常，旨在计算痴呆症患病率的综述包括研究的估计值，但没有评估其方法学质量。国际阿尔茨海默病 (ADI) 提出了一个分数来评估旨在估计痴呆症患病率的基于人群的研究的方法学质量。在过去三年中，欧盟委员会资助了三个项目（Eurodem、EuroCoDe 和 ALCOVE），以估计欧洲痴呆症的患病率。本研究的目的是对欧洲痴呆症患病率数据进行系统回顾和荟萃分析，这些数据源自仅包括根据 DSM IV 标准诊断为痴呆症且根据 ADI 标准具有高质量评分的受试者的研究。我们考虑了 EuroCoDe (1993-2007) 和 Alcove (2008-2011) 两个项目选择的研究，并进行了新的书目检索。对于系统评价，我们仅选择了包含根据 DSM IV 标准诊断为痴呆症的受试者的文章子集。使用 ADI 工具对这些研究进行定性评估。该荟萃分析考虑了 1993 年至 2018 年间在欧洲进行的 9 项研究，共有 18,263 名参与者，其中 2,137 人被诊断患有痴呆症。按年龄和性别标准化的患病率为 7.1%。这是对欧洲痴呆症患病率的首次系统评价，仅考虑采用相同诊断标准（即 DSM IV）的高质量研究。
Dementia, including Alzheimer’s disease (AD), is one of the most burdensome medical conditions. Usually, the reviews that aim at calculating the prevalence of dementia include estimates from studies without assessing their methodological quality. Alzheimer’s Disease International (ADI) proposed a score to assess the methodological quality of population-based studies aimed at estimating the prevalence of dementia. During the last three years, the European Commission has funded three projects (Eurodem, EuroCoDe, and ALCOVE) in order to estimate the prevalence of dementia in Europe. The aim of this study was to perform a systematic review and meta-analysis of data on the prevalence of dementia in Europe derived from studies that included only subjects with a diagnosis of dementia according to the DSM IV criteria, and that had a high quality score according to ADI criteria. We considered the studies selected by the two projects EuroCoDe (1993–2007) and Alcove (2008–2011), and we performed a new bibliographic search. For the systematic review, we only selected the subset of articles that included subjects with a diagnosis of dementia according to the DSM IV criteria. The studies were qualitatively assessed using the ADI tool. The meta-analysis considered 9 studies that were carried out in Europe between 1993 and 2018 including a total of 18,263 participants, of which 2,137 were diagnosed with dementia. The prevalence rate standardized for age and sex resulted 7.1%. This is the first systematic review on the prevalence of dementia in Europe considering only high-quality studies adopting the same diagnostic criteria (i.e., DSM IV).