Regulation of Channel Function Due to Coupling with a Lipid Bilayer
Regulation of Channel Function Due to Coupling with a Lipid Bilayer
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DOI：
10.1166/jctn.2012.2062
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发表时间：
2012-04-01
影响因子：
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通讯作者：
Tuszynski, J.
中科院分区：
文献类型：
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作者：
Ashrafuzzaman, Md;Tuszynski, J.
研究了由于与脂质双层的疏水耦合而对膜蛋白功能的调节。在脂质双层和不同结构的积分离子通道之间建立了基于筛选库仑相互作用近似的能量公式。我们发现疏水双层厚度通道长度不匹配会指数地导致通道不稳定，而负脂质曲率会线性地导致通道不稳定。与通道动态相关的实验参数与理论预测一致。这项研究提供了一个新的见解，可以更好地理解生物系统中膜蛋白功能的潜在机制。
Regulation of membrane protein functions due to hydrophobic coupling with a lipid bilayer is investigated. An energy formula based on the screened Coulomb interaction approximation has been developed between lipid bilayer and integral ion channels with different structures. We find that the hydrophobic bilayer thickness channel length mismatch induces channel destabilization exponentially while negative lipid curvature linearly. Experimental parameters related to channel dynamics are consistent with theoretical predictions. This study provides a new insight that provides better understanding of the underlying mechanisms of membrane protein functions in biological systems.