Botulinum toxin type A use in piriformis muscle syndrome - A pilot study
Botulinum toxin type A use in piriformis muscle syndrome - A pilot study
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DOI：
10.1097/00002060-200210000-00006
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发表时间：
2002-10-01
影响因子：
3
通讯作者：
Sherman, AK
中科院分区：
文献类型：
--
作者：
Childers, MK;Wilson, DJ;Sherman, AK
目的：本研究进行测试的假设，肌肉注射肉毒杆菌毒素A型减少慢性疼痛归因于梨状肌综合征在更大程度上比一个类似的注射与车辆（生理盐水）单独。设计：这双盲，单组，交叉研究进行了在大学门诊诊所。9名患有慢性坐骨神经痛、髋关节痛和下肢痛的女性参与了这项研究，影像学检查没有腰椎间盘突出或神经根撞击的证据。将荧光镜/肌电图引导的单侧梨状肌内注射100单位A型肉毒杆菌毒素的镇痛效果与单独注射载体的类似效果进行比较。视觉模拟疼痛量表（VASs）被用来测量疼痛强度，痛苦，痉挛，和干扰activity.Results：平均VASs检测组间无差异，在基线或注射后与车辆。然而，在基线和A型肉毒毒素注射后平均VAS之间观察到降低，但仅在四个类别中的一个类别中（干扰活动）。还将每个时间点（天）的VAS与平均基线VAS进行了比较。注射溶剂后，检测到降低，但仅在四个类别中的一个类别中（痛苦）。相比之下，注射A型肉毒杆菌毒素后，在所有VAS categories.Conclusions：VAS数据表明，肌肉注射100个单位的A型肉毒杆菌毒素梨状肌可以减少疼痛，在更大程度上比类似的注射与车辆单独。
Objective: This study was undertaken to test the hypothesis that intramuscular botulinum toxin type A decreases chronic pain attributed to piriformis muscle syndrome to a greater extent than a similar injection with vehicle (saline) alone.Design: This double-blind, single group, crossover study was performed at an outpatient university clinic. Nine women with chronic buttock, hip, and lower limb pain without evidence of lumbar disk herniation or nerve root impingement on imaging studies participated in the study. The analgesic efficacy of a fluoroscopic/electromyographically guided unilateral intramuscular piriformis injection with 100 units botulinum toxin type A was compared with a similar injection of vehicle alone. Visual analog pain scales (VASs) were used to measure pain intensity, distress, spasm, and interference with activities.Results: No differences in mean VASs were detected between groups at baseline or after injection with vehicle. However, decreases were observed between baseline and post-botulinum toxin type A injection mean VASs, but only in one of four categories (interference with activities). VASs from every time point (days) were also compared with the average baseline VASs. After injection with vehicle, decreases were detected, but only in one of the four categories (distress). In comparison, after injection with botulinum toxin type A, decreases were observed under all VAS categories.Conclusions: VAS data suggest that intramuscular piriformis injection with 100 units of botulinum toxin type A can reduce pain to a greater extent than similar injections with vehicle alone.