Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence.
Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence.
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酒精依赖个体的负面情绪处理过程中，血清素转运蛋白基因 (SLC6A4) 启动子甲基化与杏仁核反应之间缺乏关联。
DOI：
10.1093/alcalc/agz032
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Lohoff,FalkW
中科院分区：
文献类型：
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作者：
Muench,Christine;Luo,Audrey;Charlet,Katrin;Lee,Jisoo;Rosoff,DanielB;Sun,Hui;Fede,SamanthaJ;Jung,Jeesun;Momenan,Reza;Lohoff,FalkW
目的 血清素转运蛋白基因 (SLC6A4) DNA 甲基化的差异已被证明可以改变 SLC6A4 的表达并预测健康个体的大脑功能。本研究调查了酒精依赖 (AD) 个体中 SLC6A4 启动子甲基化与威胁相关杏仁核激活之间的关联。方法使用 45 名 AD 个体和 45 名健康对照 (HC) 个体的外周血 DNA 评估了 SLC6A4 启动子区域的甲基化。所有参与者都在 3-T 磁共振成像 (MRI) 扫描仪中完成了情感面部匹配任务。 结果结果并未揭示 HC 或 AD 患者中 SLC6A4 启动子甲基化变异与威胁相关杏仁核激活之间存在任何关联。此外，SLC6A4 启动子区域的甲基化在各组之间没有显着差异。结论我们的结果并没有重复之前的发现，即 SLC6A4 启动子区域甲基化的增加与健康个体中威胁相关的杏仁核激活相关，并进一步表明在 AD 个体中不存在这种关联。鉴于迄今为止对 SLC6A4 的成像表观遗传学研究数量非常有限，这些不一致的结果表明，需要未来的研究来阐明其与健康和临床人群中杏仁核反应性的关联。
AimsDifferences in DNA methylation of the serotonin transporter gene (SLC6A4) have been shown to alterSLC6A4expression and predict brain functions in healthy individuals. This study investigated the association betweenSLC6A4promoter methylation and threat-related amygdala activation in individuals with alcohol dependence (AD).MethodsMethylation of theSLC6A4promoter region was assessed using peripheral blood DNA from 45 individuals with AD and 45 healthy controls (HCs). All participants completed an emotional face matching task in a 3-T magnetic resonance imaging (MRI) scanner.ResultsResults did not reveal any association betweenSLC6A4promoter methylation variation and threat-related amygdala activation in HCs or individuals with AD. Furthermore, methylation in the promoter region ofSLC6A4did not significantly differ between the groups.ConclusionsOur results do not replicate a previous finding that increased methylation in the promoter region ofSLC6A4is associated with threat-related amygdala activation in healthy individuals and further show that there is no such association in individuals with AD. Given that the number of imaging epigenetics studies onSLC6A4is very limited to date, these inconsistent results indicate that future research is needed to clarify its association with amygdala reactivity in both healthy and clinical populations.