Defects in Bioenergetic Coupling in Schizophrenia.
Defects in Bioenergetic Coupling in Schizophrenia.
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DOI：
10.1016/j.biopsych.2017.10.014
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发表时间：
2018-05-01
影响因子：
10.6
通讯作者：
Ramsey A
中科院分区：
文献类型：
--
作者：
Sullivan CR;O'Donovan SM;McCullumsmith RE;Ramsey A
Synaptic neurotransmission relies on maintenance of the synapse and meeting the energy demands of neurons. Defects in excitatory and inhibitory synapses have been implicated in schizophrenia, likely contributing to positive and negative symptoms as well as impaired cognition. Recently, accumulating evidence suggests bioenergetic systems, important in both synaptic function and cognition, are abnormal in psychiatric illnesses such as schizophrenia. Animal models of synaptic dysfunction demonstrate endophenotypes of schizophrenia, as well as bioenergetic abnormalities. Here we report findings on the bioenergetic interplay of astrocytes and neurons and discuss how dysregulation of these pathways may contribute to the pathogenesis of schizophrenia, highlighting metabolic systems as important therapeutic targets.
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