Overexpression of IFITM3 predicts poor prognosis in stage IIA esophageal squamous cell carcinoma after Ivor Lewis esophagectomy.
Overexpression of IFITM3 predicts poor prognosis in stage IIA esophageal squamous cell carcinoma after Ivor Lewis esophagectomy.
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DOI：
10.1111/1759-7714.12488
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发表时间：
2017-11
期刊：
影响因子：
2.9
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Jia Y;Xiao Z;Jiang W;Chen G;Wang Z
最近的研究表明，IFITM3在许多恶性肿瘤的发生中发挥着重要作用。我们研究了 IFITM3 在 IIA 期食管鳞状细胞癌 (ESCC) 患者中的临床病理学变量和预后价值。使用免疫组织化学和蛋白质印迹分析来检查肿瘤标本中的IFITM3表达。分析了 IFITM3 表达与临床病理变量以及患者五年生存和复发状态之间的关系。 IFITM 3 在肿瘤组织中异常表达。统计分析显示IFITM3表达与T肿瘤状态密切相关(P = 0.004)。此外，IFITM3过表达、晚期T状态、分化程度差和肿瘤尺寸大不仅与较差的生存率相关，而且是ESCC患者淋巴转移复发的高预测因子（P<0.05）。我们的数据表明，IFITM3 过度表达可能预测 Ivor Lewis 食管切除术后 IIA 期食管鳞癌患者的不良预后。
Recent research has shown that IFITM3 plays an important role in the tumorigenesis of many malignancies. We investigated the clinicopathological variables and prognostic value of IFITM3 in stage IIA esophageal squamous cell carcinoma (ESCC) patients. Immunohistochemistry and Western blot analysis were used to examine IFITM3 expression in tumor specimens. The relationships between IFITM3 expression and clinicopathological variables, as well as the five‐year survival and recurrence status of patients, were analyzed. IFITM 3 was aberrantly expressed in tumor tissue. Statistical analysis showed a close correlation of IFITM3 expression with T tumor status (P = 0.004). Additionally, IFITM3 overexpression, advanced T status, poor degree of differentiation, and large tumor size were not only associated with poor survival but were high lymphatic metastatic recurrence predictors in ESCC patients (P < 0.05). Our data indicated that IFITM3 overexpression may predict poor prognosis in stage IIA ESCC patients after Ivor Lewis esophagectomy.
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