An experimental influenza subunit vaccine (iscom): induction of protective immunity to challenge infection in mice after intranasal or subcutaneous administration
An experimental influenza subunit vaccine (iscom): induction of protective immunity to challenge infection in mice after intranasal or subcutaneous administration
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实验性流感亚单位疫苗（iscom）：鼻内或皮下给药后诱导小鼠抵抗感染的保护性免疫
DOI：
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发表时间：
1990
影响因子：
4.6
通讯作者：
B. Morein
中科院分区：
文献类型：
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作者：
K. Lövgren;H. Kåberg;B. Morein
对一种实验性流感病毒(A/PR/8/34(H1N1))疫苗在小鼠身上进行了试验和评价。在用高剂量活病毒攻击之前，给小鼠鼻腔或皮下接种1或10μg异币一次或两次。结果表明，两次鼻腔给药与两次鼻腔给药一样有效。这两种途径都能诱导高水平的抗体，并能预防攻击性感染。使用单剂方案，S.C.途径诱导的抗体反应略高于鼻腔途径；这可能是由于与鼻腔给药有关的技术困难所致。
An experimental influenza virus (A/PR/8/34(H1N1)) vaccine was tested and evaluated in mice. The mice were inoculated once or twice intranasally or subcutancously with 1 or 10 μg of iscoins prior to challenge with high doses of live virus. It was demonstrated that two intranasal administrations were as efficient as two s.c. administrations, both routes inducing high levels of antibody and protection against challenge infection. With a one‐dose regimen, the s.c. route induced a somewhat higher antibody response than the intranasal route; this might be explained by technical difficulties connected with an intranasal administration.