Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.
Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.
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TNF-α启动子中的遗传变异是明确放疗后口咽鳞状细胞癌患者复发的预测指标。
DOI：
10.1002/ijc.28512
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发表时间：
2014-04-15
影响因子：
6.4
通讯作者：
Li, Guojun
中科院分区：
文献类型：
--
作者：
Zhang, Caiyun;Sturgis, Erich M.;Zheng, Hongliang;Song, Xicheng;Wei, Peng;Jin, Lei;Chao, Li;Wei, Qingyi;Li, Guojun
关键词：
TNF-α是免疫和炎症反应的主要调节因子，其启动子变体与癌症的发展和预后有关。因此，我们研究了四种TNF-α启动子变异体与口咽鳞状细胞癌（SCCOP）复发风险之间的关系。我们在一个846例SCCOP患者的队列中评估了4种TNF-α多态性与复发风险的相关性。使用对数秩检验和多变量考克斯模型评估相关性。与携带TNF-α −308和TNF-α −863多态性变异基因型的患者相比，携带普通纯合子基因型的患者无病生存率更低（对数秩分别为P = 0.0002和P < 0.0001）和SCCOP复发风险增加（HR，1.9，95% CI，1.3-2.8和HR，1.9，95% CI，1.3-2.7）。此外，在HPV 16阳性肿瘤患者中，TNF-α-308和-863多态性的常见纯合基因型患者的无病生存率更低（对数秩分别为P = 0.005和P = 0.007），复发风险高于这些多态性的变异基因型患者（HR，5.1，95%CI，1.4-18.4和HR，3.7，95%CI，1.5-9.1），而TNF-α −857或−1031多态性没有发现这种显著相关性。我们的研究结果表明，TNF-α −308和−863多态性可能调节HPV 16阳性肿瘤患者SCCOP复发的风险。然而，需要更大规模的研究来验证这些结果。
The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated associations of four TNF-α polymorphisms with risk of recurrence in a cohort of 846 patients with SCCOP. Log-rank test and multivariable Cox models were used to evaluate associations. Compared with patients with variant genotypes of the TNF-α −308 and TNF-α −863 polymorphisms, patients with common homozygous genotypes had worse disease-free survival (log-rank P = 0.0002 and P < 0.0001, respectively) and increased risk of SCCOP recurrence (HR, 1.9, 95% CI, 1.3–2.8 and HR, 1.9, 95% CI, 1.3–2.7, respectively) after multivariable adjustment. Furthermore, among patients with HPV16-positive tumors, those with common homozygous genotypes of the TNF-α −308 and −863 polymorphisms had worse disease-free survival (log-rank P = 0.005 and P = 0.007, respectively) and higher recurrence risk than patients with variant genotypes of these polymorphisms (HR, 5.1, 95% CI, 1.4–18.4 and HR, 3.7, 95% CI, 1.5–9.1, respectively), while no such significant associations were found for TNF-α −857 or −1031 polymorphisms. Our findings suggest that TNF-α −308 and −863 polymorphisms may modulate the risk of SCCOP recurrence in patients with HPV16-positive tumors. However, larger studies are needed to validate these results.
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影响因子：
--
作者：
Higuchi, T;Seki, N;Itoh, K
通讯作者：
Itoh, K
影响因子：
5.3
作者：
Gaudet, Mia M.;Egan, Kathleen M.;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
6.2
作者：
Ji, Xuemei;Sturgis, Erich M.;Li, Guojun
通讯作者：
Li, Guojun
TNFRSF1B +676 T> G多态性预测接受化学放疗治疗的非小细胞肺癌患者的存活。
影响因子：
3.8
作者：
Guan X;Liao Z;Ma H;Qian J;Liu Z;Yuan X;Gomez D;Komaki R;Wang LE;Wei Q
通讯作者：
Wei Q
影响因子：
45.3
作者：
Glas, J;Török, HP;Folwaczny, C
通讯作者：
Folwaczny, C