Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression.
Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression.
复制标题
精神分裂症、双向情感障碍或重度抑郁症患者儿茶酚-O-甲基转移酶表达与认知功能之间的关联分析。
DOI：
10.2147/ndt.s286102
复制
发表时间：
2021
影响因子：
3.2
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Ni P;Liu M;Wang D;Tian Y;Zhao L;Wei J;Yu X;Qi X;Li X;Yu H;Ni R;Ma X;Deng W;Guo W;Wang Q;Li T
精神分裂症、双相情感障碍和重性抑郁障碍是三种常见的精神障碍。虽然它们的诊断和治疗不同，但它们部分重叠。为了探讨这三种精神疾病的相似性和特点，进行了智商（IQ）评估，以评估认知缺陷。与健康对照组（HC）相比，在所有三个组的外周血单个核细胞中的相对儿茶酚-O-甲基转移酶（COMT）的表达进行了检查。结果表明，患有三种精神疾病中的任何一种的患者都表现出智商缺陷，并且首发精神分裂症（FES）组的认知功能甚至低于其他两组。与HC组相比，FES组COMT相对表达量降低，BD组COMT相对表达量升高。COMT表达水平与智商得分的相关性分析显示，HC组中COMT相对表达水平与全面智商呈正相关。然而，这种相关性在研究的所有三种精神疾病中都消失了。总之，这种跨疾病策略为解释三种常见精神疾病中的低智商分数和COMT表达失调提供了重要线索。
Schizophrenia, bipolar disorder (BD), and major depressive disorder are three common mental disorders. Although their diagnosis and treatment differ, they partially overlap. To explore the similarities and characteristics of these three psychiatric diseases, an intelligence quotient (IQ) assessment was performed to evaluate cognitive deficits. Relative catechol-O-methyltransferase (COMT) expression in peripheral blood mononuclear cells was examined in all three groups compared with healthy controls (HCs). The results indicated that patients with any of the three psychiatric diseases presented IQ deficits, and that the first-episode schizophrenia (FES) group had even lower cognitive function than the other two groups. The relative COMT expression decreased in the FES group and increased in the BD group compared with the HC group. The correlation analysis of COMT expression level and IQ scores showed a positive correlation between relative COMT expression and full-scale IQ in the HC group. However, this correlation disappeared in all three psychiatric diseases studied. In conclusion, this cross-disease strategy provided important clues to explain lower IQ scores and dysregulated COMT expression among three common mental illnesses.
影响因子：
3.7
作者：
Hukic DS;Frisén L;Backlund L;Lavebratt C;Landén M;Träskman-Bendz L;Edman G;Schalling M;Ösby U
通讯作者：
Ösby U