SODIUM-CHANNEL SUBTYPES IN THE RAT DISPLAY FUNCTIONAL DIFFERENCES IN THE PRESENCE OF VERATRIDINE
SODIUM-CHANNEL SUBTYPES IN THE RAT DISPLAY FUNCTIONAL DIFFERENCES IN THE PRESENCE OF VERATRIDINE
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DOI：
10.1006/bbrc.1994.1373
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发表时间：
1994-03-30
影响因子：
3.1
通讯作者：
VANDERKLOK, MA
中科院分区：
文献类型：
--
作者：
CORBETT, AM;VANDERKLOK, MA
生物碱神经毒素藜芦碱具有独特的性能，功能区分钠通道亚型在大鼠通过不同的单通道电导，通道substates和通道开放的概率。从大鼠心室肌藜芦碱激活的心脏钠通道显示了8.4 pS的单通道电导，没有证据的亚电导状态或通道亚型。大鼠骨骼肌钠通道在去极化电位下显示出高电导（8.5 pS）和低电导（4.7 pS）开放，并且开放概率（约50%）低于脑或心脏钠通道（90-95%）。大鼠脑藜芦碱激活的钠通道在去极化电位（3-6 pS）时主要显示亚电导状态，在超极化电位时显示约9.5 pS的全电导。 (C)1994年出版社出版。
The alkaloid neurotoxin veratridine has the unique property of functionally distinguishing sodium channel subtypes in the rat through differences in single channel conductances, channel substates and probability of channel opening. Veratridine-activated cardiac sodium channels from rat ventricular muscle displayed a single channel conductance of 8.4 pS with no evidence of subconductance states or channel subtypes. Rat skeletal muscle sodium channels displayed both high (8.5 pS) and low conductance (4.7 pS) openings as well as a lower probability of opening (approximately 50%) at depolarized potentials than shown with brain or cardiac sodium channels (90-95%). Rat brain veratridine-activated sodium channels displayed primarily subconductance states at depolarized potentials (3-6 pS) and full conductance of approximately 9.5 pS at hyperpolarized potentials. (C) 1994 Academic Press, Inc.