Functional connectivity and grey matter volume of the striatum in schizophrenia
Functional connectivity and grey matter volume of the striatum in schizophrenia
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DOI：
10.1192/bjp.bp.113.138099
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发表时间：
2014-09-01
影响因子：
10.5
通讯作者：
Schloesser, Ralf G. M.
中科院分区：
文献类型：
--
作者：
Koch, Kathrin;Rus, Oana Georgiana;Schloesser, Ralf G. M.
背景多巴胺能奖赏系统的改变，主要是纹状体，目的研究17名精神分裂症患者和18名健康志愿者在奖励相关试错学习过程中背侧纹状体的功能连接，并与纹状体灰质体积和精神病理学相关。基于形态测量学和心理生理学的相互作用，以检查纹状体的体积和connections.ResultsA左纹状体和颞枕区，楔前叶和颞叶之间的功能连接减少可以检测到精神分裂症组。灰质体积和左纹状体的功能连接之间的正相关性在一个非常相似的网络中产生了显着的结果。左纹状体的连通性呈负相关，阴性symptoms.ConclusionsPresent结果表明，纹状体功能连接的中断，是密切相关的纹状体的灰质形态。纹状体和精神病理学相关网络之间的连通性降低可能解释阴性症状的出现。
BackgroundAlterations in the dopaminergic reward system, predominantly the striatum, constitute core characteristics of schizophrenia.AimsFunctional connectivity of the dorsal striatum during reward-related trial-and-error learning was investigated in 17 people with schizophrenia and 18 healthy volunteers and related to striatal grey matter volume and psychopathology.MethodWe used voxel-based morphometry and psychophysiological interaction to examine striatal volume and connectivity.ResultsA reduced functional connectivity between left striatum and temporo-occipital areas, precuneus and insula could be detected in the schizophrenia group. The positive correlation between grey matter volume and functional connectivity of the left striatum yielded significant results in a very similar network. Connectivity of the left striatum was negatively correlated with negative symptoms.ConclusionsPresent results suggest a disruption in striatal functional connectivity that is closely linked to grey matter morphometry of the striatum. Decreased connectivity between the striatum and psychopathologically relevant networks may explain the emergence of negative symptoms.