Scrutineer: a computer program that flexibly seeks and describes motifs and profiles in protein sequence databases [published erratum appears in Comput Appl Biosci 1990 Oct;6(4): 431]
Scrutineer: a computer program that flexibly seeks and describes motifs and profiles in protein sequence databases [published erratum appears in Comput Appl Biosci 1990 Oct;6(4): 431]
复制标题
Scrutineer：一种计算机程序，可以灵活地寻找和描述蛋白质序列数据库中的基序和概况[已发表的勘误表出现在 Comput Appl Biosci 1990 Oct;6(4): 431]
DOI：
10.1093/bioinformatics/6.3.279
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
P. Argos
中科院分区：
文献类型：
--
作者：
P. R. Sibbald;P. Argos
Scrutineer是一个交互式的，用户友好的程序，旨在搜索Swissprot，蛋白质鉴定资源（PIR）或SeqDb蛋白质序列数据库中的基序，模式和配置文件。基本功能包括（i）搜索给定位置上具有多个选择的氨基酸串;（ii）搜索包括可变长度片段和离域约束的串;（iii）搜索数据库的子集或每个序列内的特定区域（iv）涉及二级结构预测、物理化学特征等的搜索;和（v）使用比对序列作为目标，用各种任选的加权方案进行搜索。各种搜索标准和命中可以被组合并且定位复杂的目标。一旦将数据加载到虚拟内存中，在大约36 s内发现PIR版本22.0（3.7 x 10（6）个氨基酸）中给定短氨基酸串（例如六聚体）的所有出现。Scrutineer还可以描述整个数据库，用户指定的命中，用户定义的序列区域和所有命中。源代码和附带的手册正在免费分发。
Scrutineer is an interactive, user-friendly program designed to search for motifs, patterns and profiles in the Swissprot, Protein Identification Resource (PIR) or SeqDb protein sequence databases. Basic capabilities include (i) searches for strings of amino acids with multiple choices at a given position; (ii) searches for strings including variable-length segments and delocalized constraints; (iii) searches over subsets of a database or particular regions within each sequence (e.g. N-terminal one-third); (iv) searches involving secondary structure predictions, physicochemical characteristics, and the like; and (v) searches using aligned sequences as targets with various optional weighting schemes. The various search criteria and hits can be combined and complex targets located. Once the data are loaded into virtual memory, all occurrences in PIR release 22.0 (3.7 x 10(6) amino acids) of a given short string of amino acids (e.g. a hexamer) are found in approximately 36 s. Scrutineer can also describe the entire database, user-specified hits, user-defined regions of sequence and all hits. The source code and accompanying manual are being freely distributed.