Toll receptor-mediated Drosophila immune response requires Dif, an NF-κB factor
Toll receptor-mediated Drosophila immune response requires Dif, an NF-κB factor
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DOI：
10.1101/gad.13.7.792
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发表时间：
1999-04-01
影响因子：
10.5
通讯作者：
Ip, YT
中科院分区：
文献类型：
--
作者：
Meng, XJ;Khanuja, BS;Ip, YT
果蝇中免疫基因的诱导被认为依赖于NF-κ B相关因子Dorsal、Dif和Relish。英雄，我们提供的遗传证据表明，Dif是所需的诱导只有一个子集的抗菌肽基因。结果表明，在没有Dorsal的情况下，Dif的存在足以介导柔索霉素和防御素的诱导。我们还证明，Dif是激活drosomycin表达的Toll信号通路的下游组分。这些结果表明，在果蝇NF-κ B B家族的个别成员在免疫和发育中具有不同的作用。
The induction of immunity genes in Drosophila has been proposed to be dependent on Dorsal, Dif, and Relish, the NF-kappa B-related factors. Hero we provide genetic evidence that Dif is required for the induction of only a subset of antimicrobial peptide genes. The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also demonstrate that Dif is a downstream component of the Toll signaling pathway in activating the drosomycin expression. These results reveal that individual members of the NF-kappa B family in Drosophila have distinct roles in immunity and development.