Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy.
Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy.
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个体和累积尿邻苯二甲酸盐和替代生物标志物与妊娠晚期妊娠体重增加的关联。
DOI：
10.1016/j.scitotenv.2022.158788
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Strakovsky,RitaS
中科院分区：
文献类型：
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作者：
Pacyga,DianaC;Patti,MarisaA;Papandonatos,GeorgeD;Haggerty,DianaK;Calafat,AntoniaM;Gardiner,JosephC;Braun,JosephM;Schantz,SusanL;Strakovsky,RitaS
背景/目的邻苯二甲酸酯及其替代品是内分泌/代谢干扰物，可能影响妊娠体重增加(GWG)--妊娠健康指标。方法伊利诺伊州妇女(n=299)在孕前和分娩前(中位数38周)自我报告她们的体重。计算孕前体重指数和孕龄相关GWG z得分(GWGz)。我们量化了19种邻苯二甲酸盐/替代代谢物(代表10种母体化合物)，这些代谢物来自最多5个第一天早上的尿样，大约每月收集一次，时间为8到40周。我们使用线性回归、基于分位数的g计算(QGComp)和加权分位数和回归(WQSR)来评估10个生物标记物(单个代谢物或母体摩尔和)单独或作为混合物(在四分位数范围内)与GWGz的相关性。结果邻苯二甲酸二(2-乙基己基)酯(Ʃ)、环己烷-1，2-二羧酸二(Ʃ)和对苯二甲酸二(2-乙基己基)酯(Ʃ-DEHTP)的代谢物总和与GWGz呈负相关，某些相关性具有胎儿性别特异性。当将邻苯二甲酸盐/替代品作为一种混合物进行评估时，QGComp确定Ʃ二羟基苯乙酸二乙酯、Ʃ二羟丙基苯二甲酸二异丙酯和邻苯二甲酸单(3-羧丙基)邻苯二甲酸单(3-羧丙基)酯，以及邻苯二甲酸二异酮代谢物(Ʃ二NP)和邻苯二甲酸单苄酯的总和分别是降低和提高GWGz值的显著因素，导致所有女性的GWGz值边缘相反的联合关联(β：−0.29；95%CI：−0.70，0.12)。在孕育女性的妇女中，ƩDEHP有助于边际反向联合关联(β：−0.54；95%CI：−1.09，0.03)。然而，在携带男性的女性中没有总体关联(β：0.00；95%CI：−0.60，0.59)，这可以用大致相等的负关联(由Ʃ驱动)和正关联(由Ʃ二核苷酸驱动)来解释。WQSR分析一致地复制了这些QGComp发现。结论邻苯二甲酸盐/替代品的生物标记物是胎儿性别-特异性与GWGz相关。由于Ʃ脱氢表雄酮对混合物的相关性有很大贡献，围绕这种增塑剂替代品，可能需要对孕妇进行更多的研究。
Background/aimsPhthalates and their replacements are endocrine/metabolic disruptors that may impact gestational weight gain (GWG) – a pregnancy health indicator. We investigated overall and fetal sex-specific associations of individual and cumulative phthalate/replacement biomarkers with GWG.MethodsIllinois women (n = 299) self-reported their weight pre-pregnancy and at their final obstetric appointment before delivery (median 38 weeks). We calculated pre-pregnancy body mass index and gestational age-specific GWG z-scores (GWGz). We quantified 19 phthalate/replacement metabolites (representing 10 parent compounds) in pools of up-to-five first-morning urine samples, collected approximately monthly between 8 and 40 weeks gestation. We used linear regression, quantile-based g-computation (QGComp), and weighted quantile sum regression (WQSR) to evaluate associations of ten biomarkers (individual metabolites or parent molar-sums) individually or as mixtures (in interquartile range intervals) with GWGz. We evaluated associations in all women and stratified by fetal sex.ResultsIndividually, sums of metabolites of di(2-ethylhexyl) phthalate (ƩDEHP), di(isononyl) cyclohexane-1,2-dicarboxylate (ƩDiNCH), and di(2-ethylhexyl) terephthalate (ƩDEHTP) had consistent inverse associations with GWGz, and some associations were fetal sex-specific. When evaluating phthalates/replacements as a mixture, QGComp identified ƩDEHP, ƩDEHTP, and mono-(3-carboxypropyl) phthalate, along with sum of di(isononyl) phthalate metabolites (ƩDiNP) and monobenzyl phthalate as notable contributors to lower and higher GWGz, respectively, resulting in a marginal inverse joint association in all women (β: −0.29; 95% CI: −0.70, 0.12). In women carrying females, ƩDEHP contributed to the marginal inverse joint association (β: −0.54; 95% CI: −1.09, 0.03). However, there was no overall association in women carrying males (β: 0.00; 95% CI: −0.60, 0.59), which was explained by approximately equal negative (driven by ƩDEHTP) and positive (driven by ƩDiNP) partial associations. WQSR analyses consistently replicated these QGComp findings.ConclusionsBiomarkers of phthalates/replacements were fetal sex-specifically associated with GWGz. Because ƩDEHTP contributed substantively to mixture associations, additional studies in pregnant women may be needed around this plasticizer replacement.