Stereospecific Reduction of Ethyl 2′ -Ketopantothenate to Ethyl D-(+)-Pantothenate with Microbial Cells as a Catalyst
Stereospecific Reduction of Ethyl 2′ -Ketopantothenate to Ethyl D-(+)-Pantothenate with Microbial Cells as a Catalyst
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微生物细胞催化 2′-酮泛酸乙酯立体定向还原为 D-(+)-泛酸乙酯
DOI：
10.1128/aem.56.11.3595-3597.1990
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发表时间：
1990
影响因子：
4.4
通讯作者：
Hideaki Yamada
中科院分区：
文献类型：
--
作者：
M. Kataoka;Sakayu Shimizu;Yukiko Doi;Hideaki Yamada
报道了一种新的酶催化2′ -酮泛酸酯不对称还原合成D-（+）-泛酸的方法。发现Candida macedoniensis AKU 4588几乎特异性地将2′ -酮泛酸乙酯（80 mg/ml）转化为D-（+）-泛酸乙酯（>98%对映体过量），摩尔产率为97.2%。
A novel enzymatic process for the synthesis of D-(+)-pantothenic acid through the asymmetric reduction of the 2′ -ketopantothenate ester is described. Candida macedoniensis AKU 4588 was found to convert ethyl 2′ -ketopantothenate (80 mg/ml) almost specifically to ethyl D-(+)-pantothenate (>98% enantiomeric excess), with a molar yield of 97.2%.