Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period - The Hisayama study
Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period - The Hisayama study
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DOI：
10.1161/01.str.30.7.1390
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发表时间：
1999-07-01
期刊：
影响因子：
8.3
通讯作者：
Tsuneyoshi, M
中科院分区：
文献类型：
--
作者：
Iwamoto, H;Kiyohara, Y;Tsuneyoshi, M
背景和目的：蛛网膜下腔出血是一种威胁生命的疾病，主要是由于颅内囊状动脉瘤破裂所致。然而，对一般人群中破裂和未破裂动脉瘤的患病率知之甚少。本研究的目的是通过对日本久山市普通人群30年观察期内的连续尸检系列研究，探讨颅内动脉瘤的患病率。方法：我们对1962年至1991年期间久山市居民死亡总数中的1230例连续开颅尸检病例进行了评价结果57例（4.6%）共发现73个颅内囊状动脉瘤。女性动脉瘤的患病率是男性的2.4倍（7.1%比2.9%）。在男性中，动脉瘤的患病率在各年龄组中保持不变。相比之下，40- 49岁（14.3%）和60- 69岁（14.5%）年龄组女性的动脉瘤患病率有2个高峰。最常见的动脉瘤部位为大脑中动脉（31.5%），其次为前交通动脉（30.1%）、大脑前动脉（15.1%）、椎基底动脉（12.3%）和颈内动脉（11.0%）。在这73个动脉瘤中，29个（39.7%）破裂。动脉瘤破裂在受试者中很常见
Background and Purpose-Subarachnoid hemorrhage is a life-threatening disease that occurs mostly because of the rupture of intracranial saccular aneurysms. However, little is known about the prevalence of ruptured and unruptured aneurysms in the general population. The aim of the present study was to examine the prevalence of intracranial aneurysms on the basis of a consecutive autopsy series over a 30-year observation period in a general Japanese population in Hisayama.Methods-We evaluated 1230 consecutive autopsy cases with craniotomy among the total deaths of Hisayama residents during 1962 through 1991 (overall autopsy rate, 80.1%).Results-A total of 73 intracranial saccular aneurysms were found in 57 cases (4.6%). The prevalence of aneurysms for women was 2.4 times higher than that for men (7.1% versus 2.9%). Among men, the prevalence of aneurysms remained unchanged across the range of age groups. In contrast, there were 2 peaks in the prevalence of aneurysms for women falling in the 40- to 49-year (14.3%) and 60- to 69-year age groups (14.5%). The most common site of the aneurysms was the middle cerebral artery (31.5%), followed by the anterior communicating artery (30.1%), anterior cerebral artery (15.1%), vertebrobasilar artery (12.3%), and internal carotid artery (11.0%). Among these 73 aneurysms, 29 (39.7%) were ruptured. Ruptured aneurysms were common in subjects