Exposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age
Exposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age
复制标题
中国育龄男性环境化学物质混合物的暴露概况和预测因素
DOI：
10.1016/j.chemosphere.2022.134337
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发表时间：
2022
期刊：
影响因子：
8.8
通讯作者：
Chen Da
中科院分区：
文献类型：
--
作者：
Yang Pan;Yang Jie;Hong Ao-Bo;Huang Li-Li;Xie Qi-Tong;Wang Yi-Xin;Xiong Cheng-Liang;Meng Tian-Qing;Pan An;Chen Da
个人护理产品，如添加剂，引起了人们对男性生殖健康潜在威胁的广泛关注。人类的精子发生持续约90天，这些化学物质的平均水平仍然不清楚。在我们的研究中，我们收集了每个人在1-15天，16-31天，32-63天和≥64天的尿液样本，并检查了48种典型添加剂化学品的暴露情况。通过主成分分析（PCA），k-均值聚类，和斯皮尔曼的等级相关性，然后，我们确定了6 PC分数和4集群的基础上，这些化学品的配置文件。一些工业、商业或结构类似的化学品（例如，邻苯二甲酸酯）与不相关的化学物质（例如，二苯甲酮）。PCA评分与个人生活方式相关（例如，家庭收入、茶叶消费和饮用自来水）。个人护理产品的不同暴露成分和暴露模式可能有助于男性生殖健康评估。我们建议更多关注男性广泛接触这些化学品。
Personal care products, such as additives, have raised widespread concerns about the potential threat to male reproductive health. The spermatogenesis in humans lasts for approximately 90 days, the average levels of these chemicals remain unclear during spermatogenesis. In our study, we pooled urine samples from each man during the days of 1–15, 16–31, 32–63, and ≥64, and examined exposure to 48 typical additive chemicals. By principal component analysis (PCA), k-means clustering, and Spearman's rank correlations, we then identified 6 PC scores and 4 clusters based on profiles of these chemicals. Some industrial, commercial or structural similar chemicals (e.g., phthalates) were significantly correlated compared to unrelated chemicals (e.g., benzophenone). PCA scores were associated with individual lifestyles (e.g., household income, tea consumption, and drinking tap water). Distinct exposure components and exposure patterns of personal care products may help the reproductive health assessment of men. We suggested more concerns for widespread exposure to these chemicals for men.