An operant social self-administration and choice model in mice.
An operant social self-administration and choice model in mice.
复制标题
小鼠的操作性社会自我管理和选择模型。
DOI：
10.1038/s41596-023-00813-y
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发表时间：
2023
期刊：
影响因子：
14.8
通讯作者：
Venniro,Marco
中科院分区：
文献类型：
--
作者：
Ramsey,LeslieA;Holloman,FernandaM;Lee,SamanthaS;Venniro,Marco
人们对社会因素如何影响神经生物学或神经精神障碍知之甚少。老鼠的使用使人们能够探索社会互动的神经生物学基础，提供遗传多样性和多功能性来识别社会行为的细胞类型和神经回路。然而，与大鼠相比，小鼠表现出的社交动机通常较低，这引发了一个问题，即是否应该用小鼠来模拟人类表现出的复杂社会行为。对老鼠社交行为的研究通常依赖于诸如与社交伙伴接触的时间或对社交配对环境的偏好等衡量标准，但无法评估意志(受试者控制的)对社交互动的回报。在这里，我们描述了一个意志社会自我管理和选择模型，这是我们之前在老鼠上的工作的扩展。利用小鼠，我们系统地比较了雌性青春期和成年C57BL/6小鼠以及近交系CD1小鼠，发现雌性CD1小鼠的操作性社会自我管理、隔离期间的社会寻求和选择社会互动而不是可口的食物的能力显著强于雌性C57BL/6J小鼠，与年龄无关。我们描述了建立社会自我管理和选择机制的要求，并为研究操作性社会奖励在小鼠中的作用提供了指导。我们还讨论了它在研究操作性社会奖励的大脑机制方面的应用，潜在地将其应用于神经精神障碍的小鼠模型。培训通常需要大约4周的时间进行稳定的社会自我管理，另外需要3-4周的时间进行测试，包括社交寻求和选择。
Little is known about how social factors contribute to neurobiology or neuropsychiatric disorders. The use of mice allows one to probe the neurobiological bases of social interaction, offering the genetic diversity and versatility to identify cell types and neural circuits of social behavior. However, mice typically show lower social motivation compared with rats, leading to the question of whether mice should be used to model complex social behaviors displayed by humans. Studies on mouse social behavior often rely on measures such as time spent in contact with a social partner or preference for a social-paired context, but fail to assess volitional (subject-controlled) rewarding social interaction. Here, we describe a volitional social self-administration and choice model that is an extension of our previous work on rats. Using mice, we systematically compared female adolescent and adult C57BL/6 mice and outbred CD1 mice, showing that operant social self-administration, social seeking during periods of isolation and choice of social interaction over palatable food is significantly stronger in female CD1 mice than in female C57BL/6J mice, independently of age. We describe the requirements for building the social self-administration and choice apparatus and we provide guidance for studying the role of operant social reward in mice. We also discuss its use to study brain mechanisms of operant social reward, potentially extending its application to mouse models of neuropsychiatric disorders. The training commonly requires ~4 weeks for stable social self-administration and 3–4 additional weeks for tests, including social seeking and choice.