Biologic basis for altered fractionation schemes
Biologic basis for altered fractionation schemes
复制标题
改变分馏方案的生物学基础
作者：
H. Withers
传统的方法通常不是普遍正确的，放射治疗中的剂量分割也是如此。与显示早期反应的组织和肿瘤相比，分次保留缓慢反应的组织，这表明通过将分次剂量降低到1.8至2戈伊以下可以进一步增加治疗收益。对于所有部位的所有肿瘤，放疗过程的总持续时间不应相同，因为放疗开始后再生的开始时间因组织而异，也因肿瘤而异。尽管已知生长动力学和剂量反应特征各不相同，但无法前瞻性地识别和量化它们，阻碍了个体化分次治疗方案患者的合理选择。一般来说，治愈性放疗应在尽可能短的总时间内使用最小的实际剂量进行。虽然2戈伊，每周5次可能是一个合理的“平均”治疗，更大的个体化应该是一个研究目标。
Conventional is commonly not universally correct, and so with dose fractionation in radiotherapy. Fractionation spares slowly responding tissues more than tissues and tumors that show an early response, suggesting that therapeutic gains may be further increased by reducing fractional doses below 1.8 to 2 Gy. The overall duration of a course of radiotherapy should not be the same for all tumors in all sites because the time of onset of regeneration after the start of radiotherapy varies from tissue to tissue and among tumors. Although growth kinetics and dose‐response characteristics are known to vary, inability to identify and quantify them prospectively frustrates rational selection of patients for individualized fractionation regimens. In general, curative radiotherapy should be delivered in as short an overall time as possible using the smallest practical dose per fraction. Although 2 Gy, 5 times per week may be a reasonable “average” treatment, greater individualization should be a research goal.
头颈部晚期鳞状细胞癌的同步加强放疗。
DOI：
10.1016/s0167-8140(85)80055-4
发表时间：
1985
期刊：
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
影响因子：
--
作者：
Knee,R;Fields,RS;Peters,LJ
通讯作者：
Peters,LJ
弯曲剂量：有效分割的低剂量限度。
DOI：
10.1016/0360-3016(83)90270-5
发表时间：
1983
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Tucker,SL;ThamesJr,HD
通讯作者：
ThamesJr,HD
DOI：
10.1016/0360-3016(82)90517-x
发表时间：
1982-01-01
影响因子：
7
作者：
THAMES, HD;WITHERS, HR;FLETCHER, GH
通讯作者：
FLETCHER, GH