A Study on Factors Affecting Low Back Pain and Safety and Efficacy of NSAIDs in Acute Low Back Pain in a Tertiary Care Hospital of Western Nepal
A Study on Factors Affecting Low Back Pain and Safety and Efficacy of NSAIDs in Acute Low Back Pain in a Tertiary Care Hospital of Western Nepal
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DOI：
10.7860/jcdr/2013/6520.3752
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发表时间：
2013-12-01
影响因子：
0.2
通讯作者：
Thapa, Pabin
中科院分区：
文献类型：
--
作者：
Bhattarai, Srijana;Chhetri, Himal Paudel;Thapa, Pabin
简介：下背痛的特征在于一系列症状，包括疼痛、肌肉紧张或僵硬，并且位于肩胛骨和臀部褶皱之间，有或没有扩散到腿部。非甾体抗炎药（Non-Steroidal Anti-Inflammatory Drugs，NSAIDs）是治疗急性下腰痛的首选药物。目的：探讨影响下腰痛的因素及不同非甾体抗炎药的疗效和安全性（醋氯芬酸、双氯芬酸、萘普生和尼美舒利）治疗腰痛。研究工具为资料收集表及疼痛评分量表，分别用于研究患者的人口统计学资料及疼痛严重程度。在尼泊尔Manipal教学医院骨科门诊部接受醋氯芬酸100 mg、双氯芬酸100 mg、萘普生500 mg和尼美舒利100 mg治疗急性腰痛的患者入组本研究。在随访的第5天和第10天记录疼痛评分的降低，并计算疼痛评分。采用描述性统计和Kruskal Wallis非参数检验进行分析。结果：150例患者中，女性占67.3%（n = 101）。腰痛在59 - 68岁年龄组中更常见（24.7%），并且呈正相关。同样，在从事农业、举重和不吸烟的人群中，腰痛的发病率也很高。醋氯芬酸治疗组患者平均疼痛评分下降幅度更大（4.83 +/-0.537），其次是萘普生（4.13 +/-0.067）和双氯芬酸（3.84 +/-0.086）。疼痛评分的降低在接受尼美舒利治疗的患者中最低（2.11 +/-0.148）。结论：年龄、性别、个人习惯、体位、职业、举重等因素对腰背痛有影响。醋氯芬酸的疼痛评分下降幅度更大，副作用数量更少。
Introduction: Low back pain is characterized by a range of symptoms which include pain, muscle tension or stiffness, and is localized between the shoulder blades and the folds of the buttocks, with or without spreading to the legs. Non-Steroidal Anti Inflammatory Drugs (NSAIDs) are the drugs of choice which provide an analgesic effect for acute low back pain.Aim: To study the factors affecting low back pain, efficacy and safety of different non-steroidal anti-inflammatory drugs (aceclofenac, diclofenac, naproxen and nimesulide) in low back pain.Methodology: Data collection form and numeric pain rating scale were used as study tools for studying patients' demographies and severities of pain respectively. Patients prescribed with aceclofenac 100 mg , diclofenac 100 mg, naproxen 500 mg and nimesulide 100 mg for acute low back pain at Orthopaedics Outpatients Department of Manipal Teaching Hospital, Nepal, were enrolled in this study. The decrease in pain scores was recorded on 5th and 10th days of follow-up and pain scores were calculated. Descriptive statistics and Kruskal Wallis non parametric test were used for analysis.Results: Among 150 patients, 67.3% were females (n = 101). Low back pain was more prevalent (24.7%) in age-group of 59-68 years and a positive correlation was seen. Similarly, low back pain was found to be high among people involved in agriculture, heavy weight lifters and non smokers. The decrease in average pain scores was more in the patients treated with aceclofenac (4.83 +/- 0.537), followed by that in those who were treated with naproxen (4.13 +/- 0.067) and diclofenac (3.84 +/- 0.086). The decrease in pain scores was found to be lowest among patients who were treated with nimesulide (2.11 +/- 0.148). Nimesulide presented more number of side-effects than the comparative drugs.Conclusion: Different factors affect low back pain, such as age, gender, personal habit, posture, occupation, weight lifting. Aceclofenac showed greater decrease in pain scores with lesser number of side-effects.