Acute dietary tryptophan depletion: effects on schizophrenic positive and negative symptoms.
Acute dietary tryptophan depletion: effects on schizophrenic positive and negative symptoms.
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DOI：
10.1159/000119323
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发表时间：
1997
影响因子：
3.2
通讯作者：
R. Sharma;L. Shapiro;S. Kamath;E. Soll;M. Watanabe;J. Davis
中科院分区：
文献类型：
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作者：
R. Sharma;L. Shapiro;S. Kamath;E. Soll;M. Watanabe;J. Davis
由于大脑中5-羟色胺的水平直接取决于其合成所需的外源性色氨酸（TRP）的量，因此可以通过控制饮食中TRP的量来改变相应的5-羟色胺水平。该技术已被用于探测血清素在介导各种形式的精神病理学中的作用。在这项研究中，16例符合DSM III-R标准的精神分裂症（n = 14）或情感性精神障碍（n = 2）的急性饮食TRP消耗的影响，在控制条件下进行了评估。假设是血清素的降低会导致精神障碍的“阳性”和/或“阴性”症状的减少。与基线相比，当TRP耗竭时，未发生临床或统计学显著改善。事实上，在阴性症状的测量上有统计学意义的恶化。在方法问题的背景下讨论的结果。
Because brain serotonin levels depend directly on the amounts of exogenous tryptophan (TRP) available for its synthesis, amounts of TRP in the diet may be manipulated to alter the corresponding levels of serotonin. This technique has been used for probing the role of serotonin in mediating various forms of pyschopathology. In this study, 16 patients meeting DSM III-R criteria for schizophrenia (n = 14) or schizoaffective disorder (n = 2) were assessed for the effects of acute dietary TRP depletion under controlled conditions. The hypothesis was that lowering of serotonin would result in a diminution of 'positive' and/or 'negative' symptoms of psychotic disorders. No clinically or statistically significant improvement compared to baseline occurred when TRP depletion was imposed. Indeed, there was a statistically significant deterioration on measures of negative symptoms. The results are discussed in the context of the methodological issues.