Histopathological and prognostic evaluation of immunohistochemical findings in colorectal cancer
Histopathological and prognostic evaluation of immunohistochemical findings in colorectal cancer
复制标题
DOI：
10.1177/172460089701200205
复制
发表时间：
1997-04-01
影响因子：
2
通讯作者：
Francini, G
中科院分区：
文献类型：
--
作者：
Lorenzi, M;Vindigni, C;Francini, G
许多免疫组织化学研究已经探讨了结直肠肿瘤的免疫组织化学特征与组织病理学结果之间的关系。研究最广泛的标志物之一是组织CEA，尽管这种抗原和其他抗原的预后意义仍然不确定。作者报告了用免疫组化方法测定52例结直肠癌组织标本中三种肿瘤抗原（癌胚抗原，CEA;组织多肽抗原，TPA，碳水化合物抗原19-9，CA 19-9）的结果。探讨肿瘤免疫组化特征与临床病理参数的关系及其对患者预后的影响。CEA阳性反应与肿瘤的分化程度有显著关系，而这种抗原的弥漫性细胞表达通常表明肿瘤延伸到肠壁之外并侵犯淋巴管。表达的组织抗原的数量与肿瘤通过肠壁扩散的程度显著相关。在表达组织TPA抗原或一种以上组织抗原的肿瘤中观察到更高的复发率和更短的无病间期和生存期。在本研究中，后一个参数已被证明对无病间期具有独立的预后意义。结直肠癌组织中抗原的免疫组化评价显示肿瘤抗原异质性可能具有独立的预后价值，这可能与它们不同的生物学行为有关。
Many immunohistochemical studies have investigated the relationship between immunohistochemical characteristics and histopathological findings in colorectal tumors. One of the most extensively studied markers has been tissue CEA, although the prognostic significance of this and other antigens is still uncertain. The authors report results relative to three tumoral antigens (carcinoembryonic antigen, CEA; tissue polypeptide antigen, TPA, carbohydrate antigen 19-9, CA 19-9) determined by immunohistochemical methods in tissue samples of 52 colorectal carcinomas. Th relationship between the immunohistochemical characteristics of the neoplasms and the clinicopathologic parameters, as well as their influence on the prognosis of the patients, were examined. Positive CEA reaction has a significant relationship with grade of differentiation of the tumor while diffuse cellular expression of this antigen often indicates neoplasms extending beyond the intestinal wall and invading the lymph vessels. The number of tissue antigens expressed is significantly related to the extent of tumor spread through the intestinal wall. A greater incidence of recurrence and shorter disease-free interval and survival were observed in neoplasms that expressed tissue TPA antigen or more than one tissue antigens. In the present study the latter parameter has demonstrated to have independent prognostic significance for the disease free interval. Immunohistochemical evaluation of antigens in colorectal carcinoma tissue shows a possible independent prognostic value of the antigenic heterogeneity of tumors, which could be related to their different biological behavior.