Slit and robo: expression patterns in lung development
Slit and robo: expression patterns in lung development
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DOI：
10.1016/s1567-133x(02)00095-9
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发表时间：
2003-03-01
影响因子：
1.2
通讯作者：
Kinane, TB
中科院分区：
文献类型：
--
作者：
Anselmo, MA;Dalvin, S;Kinane, TB
Slit 配体首先被描述为一种轴突引导信号，通过其对表达其受体 Roundabout (Robo) 的神经元产生排斥作用，对细胞迁移、轴突分支和伸长产生影响。间接证据表明 Slit 和 Robo 与肺部发育有关。我们现在证明 Slit-2 和 Slit-3 在小鼠胚胎肺中受到发育调节。免疫组织化学显示肺间质和气道上皮表达 Slit-2 和 Slit-3。 Robo-1 和 Robo-2 也由发育中的间充质和气道上皮表达。随着肺发育的进展，Robo-1 和 Robo-2 表达仅定位于气道上皮。我们得出结论，Slit/Robo 在时空相邻域中表达，表明在肺细支气管发育中的相互作用作用。 (C) 2003 Elsevier Science B.V. 保留所有权利。
First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrates Slit-2 and Slit-3 expression by the pulmonary mesenchyme and airway epithelium. Robo-l and Robo-2 are also expressed by the developing mesenchyme and airway epithelium. As lung development progresses, Robo-l and Robo-2 expression localizes to only the airway epithelium. We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development. (C) 2003 Elsevier Science B.V. All rights reserved.