Synthesis and characterization of highly-magnetic biodegradable poly(D,L-lactide-co-glycolide) nanospheres
Synthesis and characterization of highly-magnetic biodegradable poly(D,L-lactide-co-glycolide) nanospheres
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DOI：
10.1016/j.jconrel.2006.11.031
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发表时间：
2007-05-14
影响因子：
10.8
通讯作者：
Rosengart, Axel J.
中科院分区：
文献类型：
--
作者：
Liu, Xianqiao;Kaminski, Michael D.;Rosengart, Axel J.
本研究的目的是开发高磁化、可生物降解/生物相容性的聚合物包被磁性纳米球，用于生物医学应用。以高浓度疏水磁铁矿和聚（D，L丙交酯-羟基乙酸酯）（PLGA）为原料，采用改进的单水包油乳液-溶剂蒸发法制备了磁性球。用油酸制备的疏水磁铁矿具有高磁铁矿浓度（84 wt.%）和与生物聚合物溶剂良好的混溶性，形成稳定的油性悬浮液。然后将油状悬浮液在含有聚乙烯醇的水溶液中乳化。在有机溶剂快速蒸发后，我们得到了固体磁性纳米球。我们从外部形貌、微观结构、大小和zeta电位、纳米球内磁铁矿含量和分布以及磁性能等方面对这些纳米球进行了表征。结果表明，只有在磁铁矿浓度较高的情况下，磁铁矿才会扭曲光滑的表面形态。平均直径360 ~ 370 nm，多分散指数0.12 ~ 0.20。我们获得了高磁铁矿含量（40-60%）和高磁化强度（26-40 emu/g）。在获得高磁化性能的同时，留下了足够的聚合物来保留药物，使这些可生物降解的球体适合作为设计磁引导药物递送和其他体内生物磁性应用的潜在平台。(c) 2007年Elsevier B.V.出版
The objective of this study was to develop high magnetization, biodegradable/biocompatible polymer-coated magnetic nanospheres for biomedical applications. Magnetic spheres were prepared by a modified single oil-in-water emulsion-solvent evaporation method utilizing highly-concentrated hydrophobic magnetite and poly(D,L lactide-co-glycolide) (PLGA). Hydrophobic magnetite prepared using oleic acid exhibited high magnetite concentrations (84 wt.%) and good miscibility with biopolymer solvents to form a stable oily suspension. The oily suspension was then emulsified within an aqueous solution containing poly(vinyl alcohol). After rapid evaporation of the organic solvent, we obtained solid magnetic nanospheres. We characterized these spheres in terms of external morphology, microstructure, size and zeta potential, magnetite content and distribution within the nanospheres, and magnetic properties. The results showed good encapsulation where the magnetite distorted the smooth surface morphology only at the highest magnetite concentrations. The mean diameter was 360-370 nm with polydispersity indices of 0.12-0.20. We obtained high magnetite content (40-60%) and high magnetization (26-40 emu/g). The high magnetization properties were obtained while leaving sufficient polymer to retain drugs making these biodegradable spheres suitable as a potential platform for the design of magnetically-guided drug delivery and other in vivo biomagnetic applications. (c) 2007 Published by Elsevier B.V.