Microbubble Compositions, Properties and Biomedical Applications.
Microbubble Compositions, Properties and Biomedical Applications.
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DOI：
10.1179/175889709x446507
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Borden M
中科院分区：
文献类型：
--
作者：
Sirsi S;Borden M
在过去的十年中，微泡作为治疗诊断学在各种生物医学应用中的发展取得了重大进展。微泡对超声的独特响应能力使其成为超声造影、分子成像以及靶向药物和基因递送的有用试剂。微泡的一般组成是通过由蛋白质、脂质或聚合物组成的壳稳定的气核。每种类型的微泡都有其独特的优势，可以针对特定的功能进行定制。在这篇综述中，不同的微泡组合物和理化性质进行了讨论的背景下，目前的进展，朝着开发新的结构用于生物医学应用，特别强调分子成像和靶向药物/基因递送。
Over the last decade, there has been significant progress towards the development of microbubbles as theranostics for a wide variety of biomedical applications. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. The general composition of a microbubble is a gas core stabilized by a shell comprised of proteins, lipids or polymers. Each type of microbubble has its own unique advantages and can be tailored for specialized functions. In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery.