Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and dachshund genes
Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and dachshund genes
复制标题
DOI：
10.1073/pnas.040564497
复制
发表时间：
2000-02-29
影响因子：
11.1
通讯作者：
Furukubo-Tokunaga, K
中科院分区：
文献类型：
--
作者：
Kurusu, M;Nagao, T;Furukubo-Tokunaga, K
蘑菇体是果蝇脑中嗅觉联想学习和基本认知功能的中心。通过高分辨率的神经解剖学研究，我们发现与眼发育有关的无眼（eyeless，ey）、无眼双胞胎（twin of eyeless，Eye）和腊肠犬（dachshund，Eye）也在发育中的MB中表达。ey的突变完全破坏了MB的神经末梢，而cytokine的无效突变导致了明显的破坏和异常的轴突投射。遗传分析表明，ey和dac协同控制MB的结构发育，而这两个基因在MB发育过程中受到独立调节。这些数据认为，与眼睛发育相比，MB的调控基因具有独特的组合编码，并表明Pax6同系物在复杂大脑的嗅觉学习中心的遗传程序中的保守作用。
Mushroom bodies (MBs) are the centers for olfactory associative learning and elementary cognitive functions in the Drosophila brain. By high-resolution neuroanatomy, we show that eyeless (ey), twin of eyeless, and dachshund (dac), which are implicated in eye development, also are expressed in the developing MBs. Mutations of ey completely disrupted the MB neuropils, and a null mutation of dac resulted in marked disruption and aberrant axonal projections. Genetic analyses demonstrated that, whereas ey and dac synergistically control the structural development of the MBs, the two genes are regulated independently in the course of MB development. These data argue for a distinct combinatorial code of regulatory genes for MBs as compared with eye development and suggest conserved roles of Pax6 homologs in the genetic programs of the olfactory learning centers of complex brains.