MOLECULAR AND FUNCTIONAL-ANALYSIS OF A LYMPHOCYTE CHEMOATTRACTANT FACTOR - ASSOCIATION OF BIOLOGIC FUNCTION WITH CD4 EXPRESSION
MOLECULAR AND FUNCTIONAL-ANALYSIS OF A LYMPHOCYTE CHEMOATTRACTANT FACTOR - ASSOCIATION OF BIOLOGIC FUNCTION WITH CD4 EXPRESSION
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DOI：
10.1073/pnas.91.11.5109
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发表时间：
1994-05-24
影响因子：
11.1
通讯作者：
KORNFELD, H
中科院分区：
文献类型：
--
作者：
CRUIKSHANK, WW;CENTER, DM;KORNFELD, H
淋巴细胞趋化因子（LCF）是一种淋巴细胞产物，可刺激CD4（+）淋巴细胞、单核细胞和嗜酸性粒细胞的迁移反应。与其化学引诱活性一致，LCF诱导人T淋巴细胞表达白细胞介素2受体。在这里，我们描述了编码人LCF的cDNA的分子克隆。它是一种新的白细胞介素，与任何先前描述的细胞因子家族没有显著的同源性。对于LCF诱导的淋巴细胞迁移，LCF单体的自聚集和膜表达的CD4分子都是绝对需要的。
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4(+) lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.