Fatal adenovirus infection associated with new genome type
Fatal adenovirus infection associated with new genome type
复制标题
与新基因组类型相关的致命腺病毒感染
DOI：
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发表时间：
1998
影响因子：
12.7
通讯作者：
A. Kajon
中科院分区：
文献类型：
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作者：
A. Mistchenko;Julio F. Robaldo;F. Rosman;E. Koch;A. Kajon
由新基因组型7i引起的第一例死亡病例是一名需要长期呼吸支持的8个月大男孩，他发展为雷氏综合征、急性呼吸窘迫和闭塞性细支气管炎，并伴有致命的进化。鼻咽分泌物中检出腺病毒，住院期间持续呈阳性。酶联免疫法测定血清IgM和IgG腺病毒抗体滴度分别为1:32和1:800。EIA测定血清白细胞介素（IL）和干扰素（IFN）： IL‐2,110 pg/ml；IL‐6,300 pg/ml；IL - 8, 7000 pg/ml；TNF‐α 35 pg/ml， IL‐1和IL‐4检测不到，IFN‐α 2,200 pg/ml, IFN‐γ 700 pg/ml。病毒学研究表明分离的腺病毒属于B亚属，用Bam HI、Sma I、Bgl II和Hind III酶切病毒DNA鉴定该分离物属于基因组型7i。尸检显示闭塞性细支炎伴弥漫性肺泡损伤和静脉周围脂肪变性伴门静脉周围间隙多形核浸润。本文讨论了在减少医源性氧损伤的情况下获得充足氧合的困难。中华医学杂志，1998。©1998 Wiley‐Liss, Inc。
The first fatal case caused by the new genome type 7i is described in an 8‐month‐old boy requiring long‐term respiratory support who developed Reye's syndrome, acute respiratory distress, and bronchiolitis obliterans with fatal evolution. Adenovirus was detected in nasopharyngeal secretions and was persistently positive during hospitalization. IgM and IgG adenovirus antibody titers measured in serum by enzyme‐linked immunoassay (EIA) were 1:32 and 1:800, respectively. Serum interleukins (IL) and interferons (IFN) measured by EIA were as follows: IL‐2, 110 pg/ml; IL‐6, 300 pg/ml; IL‐8, 7,000 pg/ml; TNF‐α, 35 pg/ml, IL‐1 and IL‐4 undetectable, IFN‐α 2,200 pg/ml, and IFN‐γ 700 pg/ml. Virologic studies showed that adenovirus isolated belonged to subgenus B, and digestion of viral DNA with Bam HI, Sma I, Bgl II, and Hind III identified the isolate as belonging to genome type 7i. Autopsy showed bronchiolitis obliterans with diffuse alveolar damage and perivenular fatty degeneration with polymorphonuclear infiltrates in the periportal spaces. The difficulty in obtaining adequate oxygenation with minimization of iatrogenic oxygen injury is discussed.J. Med. Virol. 54:233–236, 1998. © 1998 Wiley‐Liss, Inc.
重组腺病毒感染后支气管上皮上 ICAM-1 的表达。
DOI：
10.1165/ajrcmb.12.2.7865213
发表时间：
1995
期刊：
American journal of respiratory cell and molecular biology.
影响因子：
--
作者：
Pilewski,JM;Sott,DJ;Wilson,JM;Albelda,SM
通讯作者：
Albelda,SM