ASPIRIN AND DIPYRIDAMOLE DECREASE INTIMAL HYPERPLASIA IN EXPERIMENTAL VEIN GRAFTS
ASPIRIN AND DIPYRIDAMOLE DECREASE INTIMAL HYPERPLASIA IN EXPERIMENTAL VEIN GRAFTS
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DOI：
10.1097/00000658-198002000-00018
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发表时间：
1980-01-01
影响因子：
9
通讯作者：
FUCHS, JCA
中科院分区：
文献类型：
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作者：
MCCANN, RL;HAGEN, PO;FUCHS, JCA
血小板释放平滑肌细胞促有丝分裂因子是血管内膜增生发病机制的假设。评价抗血小板治疗的效果。6只恒河猴接受阿司匹林（165 mg，每日两次）和潘生丁（25 mg，每日两次）给药，6只接受安慰剂给药。将双侧静脉旁路移植物置于髂动脉中。为了评价外膜夹层和内膜损伤的相对贡献，在一侧剥离颈动脉和股静脉的外膜，在另一侧通过单次通过膨胀的球囊头端导管损伤血管内膜。16周后处死动物。在移植物中，通过照相灰度法在3个标准位置测定相对管腔面积。股静脉和颈动脉被分类为组织学正常或表现出增生。所有外膜剥离的血管均正常。与药物治疗组相比，安慰剂组中除1条血管外的所有内膜损伤血管均表现出内膜增生，其中药物治疗组> 1/2正常。在所有3个位置，药物治疗动物的移植物的相对内膜面积显著较小，2个位置的管腔面积较大。抗血小板药物治疗可减少血管内膜增生。
Release from platelets of a factor mitogenic for smooth muscle cells is a postulated mechanism for the pathogenesis of vascular intimal hyperplasia. The effect of antiplatelet therapy was evaluated. Aspirin (165 mg twice daily) and dipyridamole (25 mg twice daily) were administered to 6 rhesus monkeys and 6 were given placebo. Bilateral vein bypass grafts were placed in the iliac arteries. To evaluate the relative contribution of adventitial dissection and intimal injury, on 1 side the carotid artery and femoral vein were stripped of adventitia and on the other side the intima of the vessels were injured by the single passage of an inflated balloon-tipped catheter. Animals were killed after 16 wk. In grafts relative luminal area was determined by a photographic grayimetric method at 3 standard locations. Femoral veins and carotid arteries were classified as histologically normal or as exhibiting hyperplasia. All vessels with adventitial stripping were normal. All vessels with intimal injury in the placebo group except 1 exhibited intimal hyperplasia compared to the drug-treated group in which > 1/2 were normal. Relative intimal area was significantly less in grafts from drug treated animals at all 3 locations and luminal area greater in 2. Vascular intimal hyperplasia may be reduced by treatment with antiplatelet agents.