MITOCHONDRIAL DEFECT IN BROWN ADIPOSE-TISSUE OF OBESE (OB-OB) MOUSE - REDUCED BINDING OF PURINE NUCLEOTIDES AND A FAILURE TO RESPOND TO COLD BY AN INCREASE IN BINDING
MITOCHONDRIAL DEFECT IN BROWN ADIPOSE-TISSUE OF OBESE (OB-OB) MOUSE - REDUCED BINDING OF PURINE NUCLEOTIDES AND A FAILURE TO RESPOND TO COLD BY AN INCREASE IN BINDING
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DOI：
10.1016/0006-291x(78)91036-7
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发表时间：
1978-01-01
影响因子：
3.1
通讯作者：
DESAUTELS, M
中科院分区：
文献类型：
--
作者：
HIMMSHAGEN, J;DESAUTELS, M
肥胖小鼠棕色脂肪组织线粒体中嘌呤核苷酸的核苷不敏感结合减少。将ob ob小鼠暴露于4° C不会诱导通常的结合增加。嘌呤核苷酸的核苷不敏感结合被认为是棕色脂肪组织线粒体中产热质子传导途径的量度。因此，这表明ob ob小鼠的产热受损是由于在棕色脂肪组织的线粒体，在啮齿类动物的主要产热组织在这一途径中的缺陷。这一途径的运作减少导致的更高的代谢效率可能是ob ob小鼠肥胖的基础。
Atractyloside-insensitive binding of purine nucleotides is reduced in brown adipose tissue mitochondria of the obese (ob ob) mouse. Exposure of the ob ob mouse to 4° C does not induce the usual increase in binding. Atractyloside-insensitive binding of purine nucleotides is believed to be a measure of the heat-producing proton conductance pathway in brown adipose tissue mitochondria. It is, therefore, suggested that the impaired thermogenesis of the ob ob mouse is due to a defect in this pathway in the mitochondria of the brown adipose tissue, the major thermogenic tissues in rodents. The greater metabolic efficiency which would result from a reduced operation of this pathway might be the basis for the obesity in the ob ob mouse.