Intravitreal triamcinolone acetonide combined with subthreshold grid laser treatment for macular oedema in branch retinal vein occlusion: a pilot study
Intravitreal triamcinolone acetonide combined with subthreshold grid laser treatment for macular oedema in branch retinal vein occlusion: a pilot study
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DOI：
10.1136/bjo.2007.128025
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发表时间：
2008-08-01
影响因子：
4.1
通讯作者：
Ravalico, G.
中科院分区：
文献类型：
--
作者：
Parodi, M. B.;Iacono, P.;Ravalico, G.
背景：比较单独使用红外微脉冲二极管激光的阈下网格激光治疗 (SGLT) 或联合玻璃体内注射曲安西龙 (SGLT-IVTJ) 治疗继发于视网膜分支静脉阻塞 (BRVO) 的黄斑水肿 (MO) 的有效性。方法：试点随机临床试验包括 24 名患者（24 只眼），他们被随机分配至 SGLT（13 只眼）或 SGLT-IVTJ（11 只眼）眼睛）。在研究开始时每隔 3 个月进行一次完整的眼科检查，包括糖尿病视网膜病变早期治疗研究视力、OCT 和荧光素血管造影，并计划随访 12 个月。主要结果指标是 OCT 平均黄斑中心凹厚度 (MFT) 的减少，以及在 12 个月的检查中获得至少 10 个字母（大约两行或更多行视力增加）的眼睛比例。次要结局是 OCT 上平均黄斑总体积的减少以及 MO 消退的时间。 结果：对于 3 个月检查的 SGLT-IVTJ 和 6 个月检查的 SGLP，MFT 相对于初始值的变化具有统计学意义（p
Background: To compare the effectiveness of subthreshold grid laser treatment (SGLT) with infrared micropulse diode laser alone or in combination with intravitreal triamcinolone injection (SGLT-IVTJ) for the treatment of macular oedema (MO) secondary to branch retinal vein occlusion (BRVO).Methods: Pilot randomised clinical trial including 24 patients (24 eyes) who were randomised either to the SGLT (13 eyes) or to SGLT-IVTJ (11 eyes). Complete ophthalmic examinations, including Early Treatment of Diabetic Retinopathy Study visual acuity, OCT and fluorescein angiography, were performed at the moment of the study entry and at 3-month intervals, with a planned follow-up of 12 months. Main outcome measures were the decrease in mean foveal thickness (MFT) on OCT, and the proportion of eyes that gained at least 10 letters (approximately two or more lines of visual acuity gain) at the 12-month examination. Secondary outcomes were the decrease in mean total macular volume on OCT, and the timing of MO resolution.Results: The change in MFT from the initial values was statistically significant for the SGLT-IVTJ from the 3-month examination and for the SGLP from the 6-month examination (p